Bonds and optimizing

(BQ) In this paper, attempts have been made to model and optimize process parameters in Electro-Discharge Machining (EDM) of tungsten carbide-cobalt composite (Iso grade: K10) using cylindrical copper tool electrodes in planing machining mode based on statistical techniques.

6p xuanphuongdhts 27-03-2017 35 2   Download

The aim of this study was to increase the stability of the thermolabile (ba)8-barrel enzyme indoleglycerol phosphate synthase from Escherichia coli by the introduction of disulfide bridges. For the design of such variants, we selected two out of 12 candidates, in which newly introduced cysteines potentially form optimal disulfide bonds. These variants avoid short-range connections, substitutions near catalytic residues, and crosslinks between the new and the three parental cysteines.

9p research12 01-06-2013 38 4   Download

Only 2% of the known natural products with acetylenic bonds area-alkynoates. Their polarized, conjugated triple bond is an optimal target for an enzymic hydration. Therefore they are good substrates for the enzymes involved in metabolism of acetylenic compounds, resulting in products that are suitable for bacterial growth. We isolated a Pseudomonas putida strain growing on 2-butynedioate as well as on propynoate, and determined the metabolic pathways of these two a-alkynoates.

6p tumor12 20-04-2013 28 1   Download