Cardiovascular

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 11 3   Download

Development of knowledge of cardiovascular diseases and treatments strongly depends on understanding of hemodynamic measurements. Hemodynamic parameters, therefore, have been investigated using simulation-based methods.

10p tohitohi 19-05-2020 17 1   Download

This topic is researched for two goals: Examine clinical and laboratory characteristics, coronary artery injury, coronary artery intervention in patients with acute ST-elevation myocardial infarction who receive PPCI association with TA. Assess the results, safety and the relationship between clinical, laboratory characteristics and major cardiovascular events within 12 months in patients with acute ST-elevation myocardial infarction who receive PPCI association with TA.

27p slimzslimz 21-12-2019 33 6   Download

There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function: theb1-adrenoceptors that control the cardiac contractile apparatus,the renin-angiotensin-aldo-sterone system involved in regulating bloodpressure and the natriuretic peptides contributing at least to the factors determining circulating volume.

18p research12 29-04-2013 39 3   Download

Patients with diabetes mellitus suffer from an increased incidence of complications including cardiovascular disease and cataracts; the mechanisms responsible for this are not fully understood. One characteristic of such complications is an accumulation of advanced glycation end-products formed by the adduction of glucose or species derived from glucose, such as low-molecular mass aldehydes, to proteins.

11p fptmusic 16-04-2013 31 3   Download

HAND2/dHAND is a basic helix-loop-helix transcription factor expressed in the heart and neural crest derivatives during embryogenesis. Although dHAND is essential for branchial arch, cardiovascular and limb development, its target genes have not been identified. The regulatory mech-anisms of dHAND function also remain relatively unknown. Here we report that Akt/PKB, a serine/threonine protein kinase involved in cell survival, growth and differ-entiation, phosphorylates dHAND and inhibits dHAND-mediated transcription....

11p awards 05-04-2013 46 5   Download

Homocysteine (Hcy) is anonprotein-forming sulphur amino acid that plays an important role in remethylation and trans-sulphuration processes. In recent years, it has been suggested that increased levels of plasma Hcy may play a role in the pathogenesis of various diseases, particularly at the cardiovascular level. The pathogenic mechanism of hyperhomocysteinemia, however, has not been clarified.

6p dell39 03-04-2013 54 3   Download

The metalloproteinase pregnancy-associated plasma pro-tein-A (PAPP-A) cleaves a subset of insulin-like growth factor binding proteins (IGFBP), which inhibit the activities of insulin-like growth factor (IGF). Through this proteolytic activity, PAPP-A is believed to regulate IGF bioavailability in several biological systems, including the human repro-ductive system and the cardiovascular system. PAPP-A adheres to mammalian cells by interactions with glycos-aminoglycan (GAG), thus targeting the proteolytic activity of PAPP-A to the cell surface. ...

11p dell39 03-04-2013 53 5   Download

The discovery of novel biologically active peptides has led to an explosion in our understanding of the molecular mechanisms that underlie the regula-tion of sleep and wakefulness. Urotensin II (UII), a peptide originally isolated from fish and known for its strong cardiovascular effects in mammals, is another surprising candidate in the regulatory network of sleep.

9p dell39 27-03-2013 32 4   Download

TRPP2, also called polycystin-2, the gene product ofPKD2, is a membrane protein defective in 10–15% of cases of autosomal dominant polycystic kidney disease. Mutations in PKD2 are also associated with extrarenal dis-orders, such as hepatic cystogenesis and cardiovascular abnormalities.

9p inspiron33 23-03-2013 35 4   Download

There is growing evidence that altered production and⁄or spatio-temporal distribution of reactive oxidant species and reactive nitrosative species in blood creates oxidative and⁄or nitrosative stresses in the failing myo-cardium and endothelium.

18p galaxyss3 21-03-2013 37 4   Download

Leaf extract ofGinkgo biloba(GBE) is increasingly used as a herbal medi-cine for the treatment of neurodegenerative, cardiovascular and cerebrovas-cular diseases. Several studies have demonstrated many protective effects of GBE in neurons, the endothelium and liver.

9p vinaphone15 27-02-2013 47 2   Download

Adipose tissue is an endocrine organ made up of adipocytes, various stro-mal cells, resident and infiltrating immune cells, and an extensive endo-thelial network. Adipose secretory products, collectively referred to as adipokines, have been identified as contributors to the negative conse-quences of adipose tissue expansion that include cardiovascular disease, diabetes and cancer.

9p viettel02 20-02-2013 43 5   Download

Obesity and its associated disorders, including diabetes and cardiovascular disease, have now reached epidemic proportions in the Western world, resulting in dramatic increases in healthcare costs. Understanding the pro-cesses and metabolic perturbations that contribute to the expansion of adi-pose depots accompanying obesity is central to the development of appropriate therapeutic strategies.

9p viettel02 20-02-2013 65 4   Download

The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Exam-ination of genetically engineered animal models has suggested the signifi-cance of the natriuretic peptide system in cardiovascular, renal and skeletal homeostasis.

12p cosis54 05-01-2013 43 4   Download

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions.

15p cosis54 05-01-2013 44 5   Download

Atrial natriuretic peptide (ANP) and the homologous B-type natriuretic peptide are cardiac hormones that dilate blood vessels and stimulate natri-uresis and diuresis, thereby lowering blood pressure and blood volume. ANP and B-type natriuretic peptide counterbalance the actions of the renin–angiotensin–aldosterone and neurohormonal systems, and play a cen-tral role in cardiovascular regulation.

12p cosis54 05-01-2013 35 4   Download

Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically dis-tinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyc-lases and elevating intracellular cGMP concentrations.

10p cosis54 05-01-2013 56 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Clustering and Symbolic Analysis of Cardiovascular Signals: Discovery and Visualization of

16p dauphong20 10-03-2012 39 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Changes in body weight, body composition and cardiovascular risk factors after long-term nutritional intervention in patients with severe mental illness: an observational study

8p thulanh29 18-12-2011 45 3   Download