Cell reprogramming

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  • Over recent years stem cells have stood out as a promising tool for regenerative medicine, providing alternative therapeutic solutions for a large number of diseases. Many clinical trials using stem cells or induced pluripotent stem cells are focused on the repair and regeneration of various tissues and organs in degenerative diseases, whose current treatment only succeeds in slowing down the progression of the disease.

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  • The raging ethical, religious, moral, political, and safety issues pertaining to the use of embryonic stem cells for therapy and research have prompted researchers to develop possibly better alternatives that are more efficacious and serve multiple purposes.

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  • Throughout its half a century of development, stem cell research has included two main fields: Embryonic stem (ES) cell research and the reprogramming of body somatic cells. In the present review we focused on stem cell reprogramming and its relation with otolaryngology.

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  • Nuclear Reprogramming Development naturally progresses from totipotent fertilized eggs to pluripotent epiblast cells, to multipotent cells, and finally to terminally differentiated cells. According to Waddington's epigenetic landscape, this is analogous to a ball moving down a slope. The reversal of the terminally differentiated cells to totipotent or pluripotent cells (called nuclear reprogramming) can thus be seen as an uphill gradient that never occurs in normal conditions.

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  • Trans-splicing group I ribozymes have been introduced in order to mediate RNA reprogramming (including RNA repair) of therapeutically relevant RNA transcripts. Efficient RNA reprogramming depends on the appropri-ate efficiency of the reaction, and several attempts, including optimization of target recognition and ribozyme catalysis, have been performed.

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  • Direct reprogramming of pancreatic beta cells is of great interest due to its possible use in diabetes treatment. Various studies have demonstrated direct reprogramming of insulin expressing beta cells from other somatic cells by overexpressing important pancreatic transcription factors through viral vectors.

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  • Human embryonic stem cells (hESCs) and reprogrammed human induced pluripotent stem cells (hiPSCs) proliferate indefinitely in the undifferentiated state (self-renewal) and differentiate into the three germ layers (and ultimately into all cell types (pluripotency).

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  • Primordial germ cells (PGCs) provide an excellent tool to better understand ancestor–descendent relationships as well as the efficiency and molecular mechanisms governing pluripotency in the reprogramming of somatic cells, since the latter type of cells have a relatively lower efficiency of conversion to pluripotent cells.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Induced pluripotent stem cells free of exogenous reprogramming factors...

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  • RNAreprogramming represents anewconcept incorrecting genetic defects at theRNA level.However, for the technique to be useful for therapy, the level of reprogrammingmust be appropriate. To improve the efficiency of group I ribozyme-mediated RNA reprogramming, when using theTetrahy-menaribozyme, regions complementary to the target RNA have previously been extended in length and accessible sites in the targetRNAs have been identified.

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  • This book comprises the contributions of several authors in the area of polymer characterization by atomic force microscopy of the polymer network structure formed in Ferroelectric Liquid Crystals Cells; polymerization by microwave irradiation method of starch/acrylic acid/acrylamide; polymerization of olefins; emulsion polymerization; ring opening polymerization; cationic polymerization of vinyl monomers ; block and graft copolymerization by controlled/living polymerization; fabrication of doped microstructures by two-photon polymerization; rheology of biomaterials; plant cell wall ...

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  • Nuclear cloning is a procedure to create new animals by injecting somatic nuclei into unfertilized oocytes. Recent successes in mammalian cloning with differentiated adult nuclei strongly indicate that oocyte cytoplasm contains unidentified remarkable reprogramming activities with the capacity to erase the previous memory of cell differentiation. At the heart of this nuclear reprogramming lies chromatin remodeling as chromatin structure and function define cell differentiation through regulation of the transcriptional activities of the cells....

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