Cellular trafficking

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  • Three distinct sequential cellular responses characterise the reaction of the adult spinal cord and brain to injury. An acute haemorrhagic phase immediately ensues after wounding, in which haematogenous cells flood the lesion site. This is followed by a subacute period during which macrophages clear necrotic debris, glial cell reactions are mobilised, the clot becomes organised, and scarring is initiated. Finally, the scar tissue contracts during a consolidation phase .

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  • The new strategy of ENHPS includes also the idea of a perspective change of the health promoting school network into a health promoting school movement. This idea, however, cannot be put into practice in the Czech Republic before the health promoting school model programme is tested and revised by its authors. Another reason why this idea is premature is the fact that the health promoting school model programme has not yet gained all the necessary conditions to function within the educational system.

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  • In this 3rd edition of Anatomy, Histology, and Cell Biology: PreTest Self-Assessment and Review, a significant number of changes and improvements have been made. This PreTest reviews all of the anatomical disciplines encompassing early embryology, cell biology, histology of the tissues and organs, as well as regional human anatomy of the head and neck, thorax, abdomen, pelvis, extremities, and spine. This edition represents a comprehensive effort to integrate the anatomical disciplines with clinical scenarios and cases.

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  • Gaucher disease is caused by mutations in the gene that encodes the lyso-somal enzyme acid b-glucosidase (GCase). We have shown previously that the small molecule pharmacological chaperone isofagomine (IFG) binds and stabilizes N370S GCase, resulting in increased lysosomal trafficking and cellular activity.

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  • Phosphorylated derivatives of the membrane lipid phosphatidylinositol (PtdIns), known as phosphoinositides (PIs), regulate membrane-proximal cellular processes by recruiting specific protein effectors involved in cell signalling, membrane trafficking and cytoskeletal dynamics. Two PIs that are generated through the activities of distinct PI 3-kinases (PI3Ks) are of special interest in cancer research.

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  • Many studies have investigated the intracellular trafficking of Shiga toxin, but very little is known about the underlying dynamics of its cellular recep-tor, the glycosphingolipid globotriaosyl ceramide. In this study, we show that globotriaosyl ceramide is required not only for Shiga toxin binding to cells, but also for its intracellular trafficking.

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  • Differential subcellular compartmentalization of the three main Ras isoforms (H-Ras, N-Ras and K-Ras) is believed to underlie their biological differences. Modulatable interactions between cellular membranes and Ras C-terminal hypervariable region motifs determine differences in trafficking and the relative proportions of each isoform in cell-surface signalling nanoclusters and intracellular endoplasmic reticulum⁄Golgi, endosomal and mitochondrial compartments.

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  • 4-Aminobutyrate type A (GABAA) receptor-associated protein (GABA-RAP) is a ubiquitin-like modifier implicated in the intracellular trafficking of GABAAreceptors, and belongs to a family of proteins involved in intra-cellular vesicular transport processes, such as autophagy and intra-Golgi transport.

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