Clustering of disease

A structuring and eventual exclusion of water surrounding backbone hydrogen bonds takes place during protein fold-ing as hydrophobic residues cluster around such bonds. Taken as an average over all hydrogen bonds, the extent of desolvation is nearly a constant of motion, as revealed by re-examination of the longest all-atom trajectory with explicit solvent [Y.Duan & P.A.Kollman (1998)Science 282, 740].Furthermore, this extent of desolvation is pre-served across native soluble proteins, except for cellular prion proteins....

4p research12 23-04-2013 33 2   Download

Protein misfolding and deposition underlie an increasing number of debili-tating human disorders. Alzheimer’s disease is pathologically characterized by the presence of numerous insoluble amyloid plaques in the brain, com-posed primarily of the 42 amino acid humanb-amyloid peptide (Ab42). Disease-linked mutations in Ab42 occur in or near a central hydrophobic cluster comprising residues 17–21.

11p dell39 27-03-2013 37 5   Download

Friedreich ataxia (FRDA) is a rare hereditary neurodegenerative disease characterized by progressive ataxia and cardiomyopathy. The cause of the disease is a defect in mitochondrial frataxin, an iron chaperone involved in the maturation of Fe–S cluster proteins.

12p vinaphone15 27-02-2013 31 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Phenotypic instability of Arabidopsis alleles affecting a disease Resistance gene cluster

11p panasonic06 26-12-2011 48 6   Download

Jillian J Francis*1, Martin P Eccles2, Marie Johnston3, Paula Whitty2, Jeremy M Grimshaw4, Eileen FS Kaner5, Liz Smith6 and Anne Walker1 Address: 1Health Services Research Unit, University of Aberdeen, Aberdeen, UK, 2Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK, 3College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, UK, 4Clinical Epidemiology Program, Ottawa Health Research Institute and Department of Medicine, University of Ottawa, Ontario, Canada, 5Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK and 6Manchest...

11p toshiba23 11-12-2011 49 4   Download