Delivery system

Astaxanthin (AST) and pycnogenol (PYC) are natural bioactive compounds commonly used in pharmaceuticals and functional foods due to their highly antioxidant activity and potential health benefits. However, the widespread application of astaxanthin is hindered by its poor water solubility and highly unsaturated structure. In this study, nanoparticles co-delivering astaxanthin and pycnogenol (NAP) were fabricated to enhance the dispersibility, stability, and bioavailability of astaxanthin.

9p vifilm 11-10-2024 1 0   Download

Through the process of analysing related documents and object characteristics in FMCG companies, paper aim to build vehicle roung with me window (CVRTW) model to optimize the delivering process, thus satisfying customer demand. To ensure the quality of the results, the model will be solved using the simulated annealing algorithm (SAalgorithm).

8p vifilm 11-10-2024 1 0   Download

The results show that the chloroquine phosphate loading process by material consists of two stages: surface adsorption and intra-particle diffusion. The maximum chloroquine phosphate adsorption capacity of the material reached 236 (mg/g) according to the Langmuir model.

8p vikwong 29-09-2024 5 1   Download

Mesoporous silica nanoparticles (MSNs) have been used as an anticancer drug delivery system with high safety and entrapment capacity thanks to their large internal space for drug accommodation, durable structure, and good biocompatibility. However, the treatment efficiency of the bare MSNs is limited due to its drug leakage and burst release. In this study, a phospholipid bilayer was covered on the MSNs surface (MSN@Lip) as a liposomal cap that not only reduced drug leakage but also improved the stability of the colloidal system.

8p dianmotminh02 03-05-2024 8 2   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. This study aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour. Four different brands of nasal spray were investigated.

91p runthenight04 02-02-2023 7 3   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. The thesis "Experimental Studies in Aid of Improving Nasal Drug Delivery" aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour.

91p runordie3 06-07-2022 5 3   Download

To demonstrate the practicality of two proposed model, research works are focused on as follows: O-Marketplace Model, after analyzing the limitations of existing cloud service delivery methods, a multi-cloud service delivery method is proposed to overcome these limitations, and a promising multi-cloud marketplace model is built up; Composable Application Model, we first build up its concept and its description method, then the experimentation is conducted by transform into TOSCA specification to evaluate the feasibility of the proposed multi-cloud application model.

130p viabigailjohnson 10-06-2022 14 3   Download

Research purpose: Preparation and characterization of nanocarrier systems for drug delivery system based on the modification of dendrimer (PAMAM) with biocompatible surfaces such as PNIPAM and PAA to improve the capping cisplatin.

30p extraenglish 24-05-2021 18 4   Download

Research purpose: Preparation and characterization of nanocarrier systems for drug delivery system based on the modification of dendrimer (PAMAM) with biocompatible surfaces such as PNIPAM and PAA to improve the capping cisplatin.

30p capheviahe27 23-02-2021 16 4   Download

The study has indicated that MOFs has maintained extensive applications in Biological imaging and sensing, Drug delivery systems, Methane storage, Semiconductors, Bio-mimetic mineralization, Carbon capture, Desalination/ion separation, Water vapor capture and Ferroelectrics and Multiferroics.

20p tocectocec 25-05-2020 20 1   Download

The present research aimed to give a relatively comprehensive answer to these questions using a mathematical model of the pickup and delivery system with transfers.

18p tohitohi 22-05-2020 14 1   Download

The development of drug delivery systems in the last several decades has provided a variety of methods including the synthesis new Pt(II), Pt(IV) complexes, the incorporation of drugs into liposome’s, lipid emulsions, and polymeric micelles to reduce side effects, to increase their solubility, and to prolong circulation time as well. Camphor has bioactivity, it has been used in traditional medicine from time immemorial.

6p abcxyz123_02 03-03-2020 9 1   Download

Rosuvastatin (RSV) là thuốc tổng hợp mới của nhóm statin dùng điều trị rối loạn lipid huyết, tăng cholesterol máu. Do thuộc nhóm II theo hệ thống phân loại sinh dược học nên RSV có tính tan kém, sinh khả dụng thấp (khoảng 20%).Trong số các phương pháp cải thiện tính tan và sinh khả dụng, với nhiều ưu điểm nổi trội, hệ vi tự nhũ (Self Emulsifying Drug Delivery System - SMEDDS) được chọn để nghiên cứu với mục tiêu thành lập công thức SMEDDS chứa RSV với tải lượng cao, ổn định, độ hòa tan, thấm cao và có triển vọng ứng dụng vào thực tiễn.

11p viedison2711 03-09-2019 105 6   Download

Bài viết trình bày về hệ thống chuyển giao thuốc dạng vi tự nhũ (self-microemulsifying drug delivery system, SMEDDS) thường gọi là hệ vi tự nhũ chứa cao diếp cá (DC) toàn phần (SMEDDS-DC) được điều chế nhằm cải thiện độ ổn định của quercitrin - một thành phần có hoạt tính trong cao DC, đồng thời hoạt tính kháng viêm cấp của hệ SMEDDS-DC đã được đánh giá trên mô hình gây viêm bằng carrageenan.

5p hanh_tv25 31-03-2019 35 2   Download

Pharmaceutical packaging technology structured to meet the needs of the global market, this volume provides an assessment of a wide range of issues. It covers the entire supply chain from conversion of raw materials into packaging materials and then assembled into product packs. Integrating information from many drug delivery systems, the author discusses testing and evaluation and emphasizes traceability and the need to for additional safeguards.

459p phongluu9x 22-10-2014 82 5   Download

We have analyzed the response of a number of human cell lines to treatment with antisense oligodeoxynucleotides (ODNs) directed against RNA polymerase II, replication protein A, and Ha-ras. ODN-delivery to the cells was liposome-mediated or via electroporation, which resulted in di€erent intracellular locations of the ODNs. The ODN-mediated target mRNA reduction varied consider-ably between the cell lines.

10p research12 23-04-2013 38 3   Download

Special oligonucleotides for targeted gene correction have attracted increasing attention recently, one of which is the chimericRNAÆDNAoligonucleotide (RDO) system. RDOs for targeted gene correction were first designed in 1996, and are typically 68 nucleotides in length including continuous RNA andDNA sequences (RNA is 2¢-O-methyl-modified).

6p tumor12 22-04-2013 33 2   Download

a2 -Macroglobulin (a2M) is an abundant glycoprotein with the intrinsic capacity for capturing diverse proteins for rapid delivery into cells. After internalization by the receptor-mediated endocytosis,a2M-protein complexes were rapidly degraded in the endolysosome system. Although this is an importantpathway for clearanceofbotha2Mandbiological targets, little is known about the nature ofa2M degradation in the endolysosome system.

10p tumor12 20-04-2013 33 3   Download

A bio-nanocapsule (BNC), composed of the surface antigen (sAg) of the hepatitis B virus, is an efficient nanomachine with which to accomplish the liver-specific delivery of genes and drugs. Approximately 110 molecules of sAg are associated to form a BNC particle with an average diameter of 130 nm. TheLprotein is an sAg peptide composed mainly of preS and S regions. The preS region, with specific affinity for human hepatocytes, is localized in the N-terminus.

10p fptmusic 11-04-2013 37 2   Download

Glutamine is an essential amino acid for enterocytes, especially in states of critical illness and injury. In several studies it has been speculated that the beneficial effects of glutamine are dependent on the route of supply (lumi-nal or systemic). The aim of this study was to investigate the relevance of both routes of glutamine delivery toin vitro intestinal cells and to explore the molecular basis for proposed beneficial glutamine effects: (a) by deter-mining the relative uptake of radiolabelled glutamine in Caco-2 cells;...

15p fptmusic 11-04-2013 46 2   Download