Discovery and development

The recent discovery of theNogo family ofmyelin inhibitors and theNogo-66 receptor opens upa very promising avenue for the development of therapeutic agents for treating spinal cord injury. Nogo-A, the largest member of the Nogo fam-ily, is a multidomain protein containing at least two regions responsible for inhibiting central nervous system (CNS) regeneration. So far, no structural information is available for Nogo-A or any of its structural domains. We have sub-cloned and expressed two Nogo-A fragments, namely the 182 residueNogo-A(567–748) and the 66 residueNogo-66 in Escherichia coli..

11p dell39 03-04-2013 48 4   Download

Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of polyamines – basic regulators of cell growth and prolifer-ation. The discovery of selective inhibitors of PAO and SMO represents an important tool in studying the involvement of these enzymes in polyamine homeostasis and a starting point for the development of novel antineoplas-tic drugs.

9p inspiron33 26-03-2013 41 5   Download

Shikimate dehydrogenase (SDH) is the fourth enzyme involved in the shiki-mate pathway. It catalyzes the NADPH-dependent reduction of 3-dehy-droshikimate to shikimate, and has been developed as a promising target for the discovery of antimicrobial agent. In this report, we identified a new aroEgene encoding SDH fromHelicobacter pyloristrain SS1. The recom-binantH.

11p inspiron33 23-03-2013 20 2   Download

Hepatitis C virus is a human pathogen responsible for liver diseases includ-ing acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma. Its high prevalence, the absence of a prophylactic vaccine and the poor effi-ciency of current therapies are huge medical problems. Since the discovery of the hepatitis C virus, our knowledge of its biology has been largely punctuated by the development of original models of research.

14p media19 04-03-2013 33 3   Download

Malaria vaccine discovery and development follow two principal strategies. Most subunit vaccines are designed to mimic naturally acquired immunity that develops over years upon continuous exposure to Plasmodiumtrans-mission. Experimental model vaccines, such as attenuated live parasites and transmission-blocking antigens, induce immune responses superior to naturally acquired immunity.

8p media19 04-03-2013 39 2   Download

The discovery that microRNAs (miRNAs) are synthesized as hairpin-con-taining precursors and share many features has stimulated the development of several computational approaches for identifying new miRNA genes in various animal species.

7p viettel02 22-02-2013 41 3   Download

Heat shock factors form a family of transcription factors (four in mam-mals), which were named according to the first discovery of their activation by heat shock. As a result of the universality and robustness of their response to heat shock, the stress-dependent activation of heat shock factor became a ‘paradigm’: by binding to conserved DNA sequences (heat shock elements), heat shock factors trigger the expression of genes encoding heat shock proteins that function as molecular chaperones

23p viettel02 19-02-2013 42 5   Download

In the early 1990s, breakthrough discoveries on the genetics of Alzheimer’s disease led to the identification of missense mutations in the amyloid-b precursor proteingene. Research findings quickly followed, giving insights into molecular pathogenesis and possibilities for the development of new types of animal models.

21p mobifone23 18-01-2013 41 5   Download

The discovery that signaling by the epidermal growth factor receptor (EGFR) plays a key role in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different types of EGFR-targeted ther-apeutic agents were subsequently developed: mAbs, such as cetuximab and panitumumab, which target the extracellular domain of the receptor,

7p mobifone23 18-01-2013 46 3   Download

Detection of cancer at early stages that can be treated through surgery is a difficult task. One methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by cancer cells have altered glycan structures, although the proteins themselves are common, ubiquitous, abundant, and familiar.

11p mobifone23 18-01-2013 33 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: ESTs from a wild Arachis species for gene discovery and marker development

10p panasonic06 26-12-2011 41 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The first set of EST resource for gene discovery and marker development in pigeonpea (Cajanus cajan L.)

22p panasonic06 25-12-2011 65 4   Download