Discovery and development

Xem 1-20 trên 216 kết quả Discovery and development
  • For the last 60 or so years the chemotherapy of bacterial infections has been dominated by natural products and their semi-synthetic variants. Although the term antibiotic was initially used exclusively to describe those anti-bacterials of natural or semi-synthetic origin, it has become broadened in common usage to include antibacterial agents of purely synthetic origin as well. The emphasis of this chapter will be on the discovery of novel prototype structures that represent the different classes of antibiotic e.g.

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  • Complex software-based systems today power the Nation’s most advanced defense, security, and economic capabilities. Such systems also play central roles in science and engineering discovery, and thus are essential in addressing this century’s grand challenges (e.g., low-cost, carbon-neutral, and renewable energy; clean water; next-generation health care; extreme manufacturing; space exploration, etc.). These large-scale systems typically must remain operational, useful, and relevant for decades.

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  • Drug discovery and development has been aided by high throughput screening methods that detect compound effects on a single target. However, when using focused initial screening, undesirable secondary effects are often detected late in the development process after significant investment has been made.

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  • Medicinal chemistry is a discipline at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents (drugs). Compounds used in medical applications are most often organic compounds, which are often divided into the broad classes of small organic molecules and biologics, the latter of which are most often medicinal preparations of proteins. Inorganic and organometallic compounds are also useful as drugs.

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  • Worldwide, crude oil demand is unceasingly increasing. As a response, Enhanced Oil Recovery (EOR) processes have re‐gained interest from the research and development phases to the oilfield EOR implementation stage. This renewed interest has been also furthered by the current high oil price environment, the maturation of oilfields worldwide, and few new‐well discoveries. Concurrently, environmental concerns and public pressure related to crude oil pollution control and remediation of oilcontaminated sites are becoming greater than ever....

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  • Serum prostate specific antigen (PSA) is the only biomarker routinely used for the early detection of prostate cancer, but it is not a perfect test. Although PSA is highly specific for prostate, an elevated level is not specific for cancer, being increased in benign hyperplasia and prostatitis (Pungalia, 2006; Bozeman, 2002). Consequently, the majority of men with an increased serum PSA do not have prostate cancer and thus undergo unnecessary prostate biopsies.

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  • All other aspects of Marketing and Innovation remain fairly steady, but businesses continue to have difficulty promoting their businesses effectively to increase sales. Success in the Workforce area slipped this wave, as small businesses feel less successful in training and developing employees (only 58 percent are highly successful compared to 65 percent a year ago). They do moderately well in maximizing employee productivity and rewarding employees. Customer Service is an area where small businesses continue to shine.

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  • Pursuant to the Privacy Act of 1974 (5 U.S.C. 552a) (Privacy Act), HUD published in the Federal Register on July 17, 2012, at 77 FR 41997, a notice that announced a new system of records for OGC’s E-Discovery Management System (OGC-EDMS), a system expected to significantly improve the efficiency of OGC’s processing of records during the preservation, discovery, and processing of litigation requests when litigation is “reasonably anticipated”1 and reduce the time HUD staff spend on the document review and production process.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The first set of EST resource for gene discovery and marker development in pigeonpea (Cajanus cajan L.)

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: ESTs from a wild Arachis species for gene discovery and marker development

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  • The discovery that microRNAs (miRNAs) are synthesized as hairpin-con-taining precursors and share many features has stimulated the development of several computational approaches for identifying new miRNA genes in various animal species.

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  • This paper reports on exploratory research to identify the most important legal and economic implications of electronic discovery and to develop a research plan in this subject area for the RAND Institute for Civil Justice. To achieve these objectives, we reviewed the current state of electronic discovery (e-discovery) law and practices, including the main features of the new federal rules, interviewed several experts in electronic discovery issues as well as in-house counsel for a number of very large corporations, conducted an initial...

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  • Since biomarkers of safety and efficacy are becoming tools in drug development, it is necessary to determine whether these biomarkers can qualify for applications in clinical trials. Qualification is defined as “a conclusion that the biomarker data submitted support use of the biomarker in drug discovery, drug development or post approval studies and where appropriate, in regulatory decision making” (ICH E-16). A definition of validation was proposed during the workshop.

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  • part 1 book “anticancer agents from natural products” has contents: introduction, camptothecin and its analogs, the discovery and development of the combretastatins, homoharringtonine and related compounds, podophyllotoxins and analogs, the vinca alkaloids, chemistry and biology of the discodermolides, potent mitotic spindle poisons,… and other contents.

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  • The raging ethical, religious, moral, political, and safety issues pertaining to the use of embryonic stem cells for therapy and research have prompted researchers to develop possibly better alternatives that are more efficacious and serve multiple purposes.

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  • Preclinical research implementing fluorescence-based approaches is inevitable for drug discovery and technology. For example, a variety of contrast agents developed for biomedical imaging are usually evaluated in cell systems and animal models based on their conjugation to fluorescent dyes.

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  • Fibroblast growth factor receptor 1 (FGFR1) is correlated closely with the occurrence and development of lung cancer. FGFR1 kinase inhibitors have exhibited significant therapeutic effects against non-small-cell lung cancer. Recently, non-ATP competitive FGFR1 inhibitors have attracted extensive attention due to their low side effects.

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  • Metabolomics is one of most recent omics technologies. It has been applied on fields such as food science, nutrition, drug discovery and systems biology. For this, gas chromatography-mass spectrometry (GC-MS) has been largely applied and many computational tools have been developed to support the analysis of metabolomics data. Among them, AMDIS is perhaps the most used tool for identifying and quantifying metabolites.

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  • Biomarkers and target-specific phenotypes are important to targeted drug design and individualized medicine, thus constituting an important aspect of modern pharmaceutical research and development. More and more, the discovery of relevant biomarkers is aided by in silico techniques based on applying data mining and computational chemistry on large molecular databases.

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  • This module teaches students how to publish Web Services and locate Web Services using the Microsoft® Universal Description, Discovery, and Integration (UDDI) software development kit (SDK). A local development UDDI registry is used in the demonstrations and lab for this module, but the mechanics of publishing and finding Web Services is no different on the public UDDI registry nodes.

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