Discovery and development

This document is a summation of our three-year engagement with the RMIT Masters program. However, in being both conclusive and projective, a particular structure has evolved which runs as closely as it can to the threefold structure of the Masters while also encompassing the particularity of our process and our discoveries. The serendipity which seems to impress every RMIT Masters candidate in respect to the alignment of the program and their practice development ha also left its mark upon us.

68p runthenight07 01-03-2023 1 1   Download

Peanut is one of the primary sources for vegetable oil worldwide, and enhancing oil content is the main objective in several peanut breeding programs of the world. Tightly linked markers are required for faster development of high oil content peanut varieties through genomics-assisted breeding (GAB), and association mapping is one of the promising approaches for discovery of such associated markers.

12p vihagrid 30-01-2023 4 3   Download

Ebook Fulfilling the promise of technology transfer: Fostering innovation for the benefit of society – Part 1 presents the following content: Chapter 1 - Technology transfer from Keio University: Development of professionals fostering innovation over the past decade; Chapter 2 - Does technology transfer from universities to industry contribute to innovation? Chapter 3 - Commercializing promising but Dormant Japanese Industry – University Joint Discoveries via Independent, Venture Ca...

64p runthenight03 07-12-2022 11 2   Download

Colorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous physiological functions are proved to be involved in the development of CRC. However, there is no lipidomic study with large-scale serum samples on diagnostic biomarkers for CA.

14p viangelamerkel 27-07-2022 5 1   Download

Climate change and accelerating socioeconomic developments increasingly challenge environmental problems in the Vietnamese Mekong Delta (VMD) – a typical large, economically dynamic, and highly vulnerable delta. The amount of people exposed to climate changes in VMD is estimated to increase shortly. This paper collects information of the important discoveries about future climate changes from the global climate models (GCMs) indicating that VMD will likely be warmer in the future with an average temperature over 1.5o C and sea-level rise (SLR) will be 100cm in 2100s.

10p vistephenhawking 26-04-2022 11 1   Download

3′ Untranslated regions (3' UTRs) length is regulated in relation to cellular state. To uncover key regulators of poly(A) site use in specific conditions, we have developed PAQR, a method for quantifying poly(A) site use from RNA sequencing data and KAPAC, an approach that infers activities of oligomeric sequence motifs on poly(A) site choice.

17p vimichaelfaraday 25-03-2022 9 1   Download

A contains over 150 types of chemical modifications. Although many of these chemical modifications were discovered several decades ago, their functions were not immediately apparent. Discoveries of RNA demethylases, along with advances in mass spectrometry and high-throughput sequencing techniques, have caused research into RNA modifications to progress at an accelerated rate.

9p vialfrednobel 29-01-2022 2 0   Download

It is important for large-scale epigenomic studies to determine and explore the nature of hidden confounding variation, most importantly cell composition. We developed MeDeCom as a novel reference-free computational framework that allows the decomposition of complex DNA methylomes into latent methylation components and their proportions in each sample.

20p vialfrednobel 29-01-2022 9 0   Download

: Spatiotemporal changes in the chromatin accessibility landscape are essential to cell differentiation, development, health, and disease. The quest of identifying regulatory elements in open chromatin regions across different tissues and developmental stages is led by large international collaborative efforts mostly focusing on model organisms, such as ENCODE.

20p viarchimedes 26-01-2022 9 0   Download

A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing together with a new computational pipeline (FLAMES) is developed to enable isoform discovery, splicing analysis, and mutation detection in single cells.

24p viarchimedes 26-01-2022 11 0   Download

Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional structures than benign variants. Motivated by this tendency, we develop a fast and powerful protein-structure-based scan (PSCAN) approach for evaluating gene-level associations with complex disease and detecting signal variants.

25p viarchimedes 26-01-2022 6 0   Download

Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes.

32p viarchimedes 26-01-2022 5 0   Download

Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols.

18p viarchimedes 26-01-2022 7 1   Download

Identifying genotype-phenotype links and causative genes from quantitative trait loci (QTL) is challenging for complex agronomically important traits. To accelerate maize gene discovery and breeding, we present the Complete-diallel design plus Unbalanced Breeding-like Inter-Cross (CUBIC) population, consisting of 1404 individuals created by extensively inter-crossing 24 widely used Chinese maize founders.

17p viarchimedes 26-01-2022 11 0   Download

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. microRNAs’ ability to regulate multiple targets could hold a promising discovery approach to pathways relevant for TNBC aggressiveness.

19p vielonmusk 21-01-2022 6 0   Download

With the following report we want to present an unusual case of a patient suffering from acute respiratory distress syndrome with early discovery of bacterial pathogens in bronchoalveolar liquid samples that developed a fatal undiscovered disseminated fungal infection.

7p vizhangzhidong 29-12-2021 8 0   Download

A series of N-acylhydrazone derivatives (2a–2p) containing 6-methoxy-naphthalene and acylhydrazone moieties were synthesized in good yield using microwave irradiation and developed as potential COX-2 inhibitors. Furthermore, the interactions between COX-2 and the compounds were examined in detail by molecular modeling studies such as structure–activity relationship and molecular docking performed using Gaussian 09 and Discovery Studio 3.5.

20p langthannam 29-12-2021 4 0   Download

This mixed-methods study explores teachers, principals, and supervisors’ personal experiences with and perspectives on the features of Discovery Education professional development (PD) programs as a transformative PD (TPD) model, which is implemented as a key component of current educational reforms in Egypt

12p lazzaro 30-12-2021 8 0   Download

This paper describes how collaboration for knowledge creation in an area-based sufficiency rural development in Thailand works in coping with complex rural problems and needs. Based on extensive field observation in the implementation of the Royal Initiatives Discovery Institute's projects in two provinces over the past two years.

6p guernsey 28-12-2021 5 0   Download

In the present study, wrinkled surfaces were discovered on the cell wall thickenings of helical vessels in the lilac style for the first time. The structure of the wrinkles was formed by cellulose microfibrils, with convex ridges composed of crystalline cellulose and concave grooves composed of amorphous cellulose. The cellulose microfibrils were oriented with the helical cell wall thickenings. The wrinkle morphology was due to the aligned crystalline region of the microfibrils.

8p tudichquannguyet 29-11-2021 6 0   Download