Drug dynamics

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  • Public opinion on the medical value of marijuana has been sharply divided. Some dismiss medical marijuana as a hoax that exploits our natural compassion for the sick; others claim it is a uniquely soothing medicine that has been withheld from patients through regulations based on false claims. Proponents of both views cite “scientific evidence” to support their views and have expressed those views at the ballot box in recent state elections.

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  • In this book, the term Zen is used to roll together all of these con- cepts. This is not an orthodox treatment of Zen. The book could have been called the Yoga, Tao, or Way of Managing Projects. In the end all of these terms are pointing to the same basic strategy—regard every- thing as a part of a holistic, integrated system, set your intention to include all of your personal and nonpersonal goals, apply objectivity and subjectivity in dynamic balance, seek to perfect yourself and your performance while not being hung up about your imperfections, and recognize that a...

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  • The marketing of agricultural commodities in the United States is done by a private enterprise system. It involves millions of individual decisions (to grow, to buy, to sell, to store, to ship) on the part of farmers, marketing men, and consumers. Agricultural marketing is a huge national and international operation. The marketing system is intricate. It is sensitive to many economic and international developments, which include strikes, weather, political upheavals and related factors that affect marketing activities.

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  • This balanced relationship is the basis of the underlying hypothesis of work undertaken by Arts Access International (www.artsaccessinternational.org). The hypothesis states that: “the way, from within ourselves, we look outwards at the world around us influences our perception of factors in the external environment that impinge on us and how we respond to them. The relationship is dynamic and symbiotic”.

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  • This is the third volume in the series “Tutorial in Mathematical Biosciences”. These lectures are based on material which was presented in tutorials or developed by visitors and postdoctoral fellows of the Mathematical Biosciences Institute (MBI), at The Ohio State University. The aim of this series is to introduce graduate students and researchers with just a little background in either mathematics or biology to mathematical modeling of biological processes. The first volume was devoted to mathematical neuroscience, which was the focus of the MBI program in 2002–2003.

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  • Socio-Ecological Landscape Units (SELU) are produced in turn from LCFU and other geographical dimensions such as relief, belonging to a river basin, or proximity to the sea. LCFU are agglomerated with a methodology which maps dominant land‑cover types. Large forests or agricultural areas will constitute a SELU in their own right while smaller units will be part of a larger zone characterised by its dominant land cover. The Dominant Land Cover Types are then classified according to river basins and relief classes (e.g. coastal, lowland, highland, mountain).

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  • We find that dynamically consistent (exponential) impatience cannot explain the magnitude of the decline. The model needs either an implausibly large degree of annual impatience, or a very large intertemporal elasticity of substitution. Intuitively, the problem arises because the exponential discount rate is constant over time:1 even a mild degree of short-run discounting, say a daily discount rate of 1 percent, implies a daily discount factor of 0.99 and thus an annual discount factor of 0.99365 = 0.03.

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  • Peer-to-peer systems and applications are distributed systems without any centralized control or hierarchical organization, in which each node runs software with equivalent functionality. A review of the features of recent peer-to-peer applications yields a long list: redundant storage, permanence, selection of nearby servers, anonymity, search, authentication, and hierarchical naming. Despite this rich set of features, the core operation in most peer-to-peer systems is efficient location of data items.

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  • The Internet has become an important form of communication in modern society, with a forecast of 500 million online globally by the year 2003. 1 Its increased use and accessibility have led to a burgeoning of cyber communities, where people of like minds and common interests transcend geographical barriers and communicate with one another on a range of subjects, some trivial, some controversial, and some intensely private.

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  • Health care workers should explain the importance of directly observed treatment as a standard of care for all patients. The health worker must watch the patient swallow all the drugs. This will ensure that the patient takes the correct drugs regularly for the required time. If injections are needed, they will be given properly. For example, if the patient does not take all of the drugs, he or she will continue to spread TB to others, and his or her TB will not be cured. It is dangerous to stop or interrupt treatment, because then...

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  • Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.

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  • Enolase is a validated drug target inTrypanosoma brucei. To better charac-terize its properties and guide drug design efforts, we have determined six new crystal structures of the enzyme, in various ligation states and confor-mations, and have carried out complementary molecular dynamics simula-tions.

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  • We consider the problem of optimal investment in a risky asset, and in derivatives written on the price process of this asset, when the underlying asset price process is a pure jump L´ evy process. The duality approach of Karatzas and Shreve is used to derive the optimal consumption and investment plans. In our economy, the optimal derivative payoff can be constructed from dynamic trading in the risky asset and in European options of all strikes.

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  • Tham khảo sách 'marijuana and medicine: assessing the science base', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Penicilliumantifungal protein (PAF) is a promising antimycotic without toxic effects on mammalian cells and therefore may represent a drug candi-date against the often lethalAspergillusinfections that occur in humans. The pathogenesis of PAF on sensitive fungi involves G-protein coupled sig-nalling followed by apoptosis.

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  • Some of the poorest countries have significantly reduced maternal and newborn mortality and improved women’s and children’s health. Innovative approaches can achieve even more, eliminating barriers to health and producing better outcomes. These approaches need to be applied to all activities: leadership, financing (including incentives to achieve better performance and results), tools and interventions, service delivery, monitoring and evaluation.

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  • The most important trend in biological engineering is the dynamic range of scales at which biotechnology is now able to integrate with biological processes. An explosion in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug delivery into cells, miniaturized implantable microsensors for medical diagnostics, and micro-engineered robots for on-board tissue repairs. This book aims to provide an upto- date overview of the recent developments in biological engineering from diverse aspects and various applications in clinical and experimental research....

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  • MODELLING AIDS EPIDEMIC AND TREATMENT WITH DIFFERENCE EQUATIONS K. M. TAMIZHMANI, A. RAMANI, B. GRAMMATICOS, AND A. S. CARSTEA Received 15 October 2003 and in revised form 10 March 2004 We propose two models for the description of the dynamics of an AIDS epidemic and of the effect of a combined-drugs AIDS treatment based on difference equations. We show that our interacting population model, despite its extreme simplicity, describes adequately the evolution of an AIDS epidemic. A cellular-automaton analogue of the discrete system of equations is presented as well.

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  • Carbon-based nanoparticles and nanostructures, such as carbon nanotubes (CNTs), have drawn great attention in both academia and industry due to their wide potential applica‐ tions. Owing to their well-defined one-dimensional (1D) interior, CNTs serve as desirable materials for encapsulating molecules, such as water [1-4], ionic liquid [5], drug molecules [6], and biomolecules [7].

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  • This book does not provide a comprehensive overview of Multiple Myeloma but a collection of chapters with in-depth information of distinct hot topics in the diagnostic, research and therapeutic fields. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to the creation of super cocktails. Curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world.

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