Drug kinetics

Xem 1-12 trên 12 kết quả Drug kinetics
  • enzymes are powerful biological catalysts that are essential for the proper maintenance and propagation of any organism. these properties make them excellent candidates as therapeutic targets to combat diseases of either genetic or pathogenic origin. in this regard, one goal of molecular medicine is to develop and implement effective agents that can modulate the activity of various enzymes involved in essential biological pathways. the process of developing and characterizing these small molecules, i.e., rational drug design, often requires a priori knowledge of the enzyme in question....

    pdf29p sinh_30 27-09-2010 84 14   Download

  • There continues to be an explosion of research on issues of pharmacologic relevance to primary eye care delivery. New ophthalmic formulations are being developed, new diagnostic methods introduced,and new medications and delivery systems are available that were unheard of a decade ago. It is important that these new concepts be introduced to students and practitioners alike.

    pdf777p mnemosyne75 02-02-2013 29 6   Download

  • (BQ) Part 2 book "Essentials of pharmaceutical chemistry" has contents: Volumetric analysis of drugs, analytical spectroscopy, stability of drugs and medicines, kinetics of drug stabilityb, licensing of drugs and the British Pharmacopoeia, answers to problems.

    pdf148p bautroibinhyen20 06-03-2017 20 5   Download

  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets

    pdf11p toshiba17 31-10-2011 36 2   Download

  • Adequate aqueous solubility of new chemical entities (NCEs) is one of the key properties required for successful pharmaceutical formulation development. Solubility is generally defi ned as the concentration of the compound in a solution which is in contact with an excess amount of the solid compound when the concentration and the solid form do not change over time (Sugano et al. 2007 ) .

    pdf659p thienbinh1311 13-12-2012 40 2   Download

  • Many protein substrates of caspases are cleaved at noncanonical sites in comparison to the recognition motifs reported for the three caspase sub-groups. To provide insight into the specificity and aid in the design of drugs to control cell death, crystal structures of caspase-7 were determined in complexes with six peptide analogs (Ac-DMQD-Cho, Ac-DQMD-Cho, Ac-DNLD-Cho, Ac-IEPD-Cho, Ac-ESMD-Cho, Ac-WEHD-Cho) that span the major recognition motifs of the three subgroups.

    pdf14p media19 04-03-2013 14 2   Download

  • Liver microsomal preparations are routinely used to predict drug interactions that can occurin vivo as a result of inhi-bition of cytochrome P450 (CYP)-mediated metabolism. However, the concentration of free drug (substrate and inhibitor)at its intrahepatic site of action, a variable that cannot be directly measured, may be significantly different from that in microsomal incubation systems.

    pdf10p tumor12 20-04-2013 15 2   Download

  • The structural and kinetic effects of amprenavir (APV), a clinical HIV pro-tease (PR) inhibitor, were analyzed with wild-type enzyme and mutants with single substitutions of V32I, I50V, I54V, I54M, I84V and L90M that are common in drug resistance. Crystal structures of the APV complexes at resolutions of 1.02–1.85 A ˚ reveal the structural changes due to the muta-tions.

    pdf16p viettel02 19-02-2013 16 1   Download

  • p38 Mitogen-activated protein kinase alpha (p38 MAPKa) is a member of the MAPK family. It is activated by cellular stresses and has a number of cellular substrates whose coordinated regulation mediates inflammatory responses. In addition, it is a useful anti-inflammatory drug target that has a high specificity for Ser-Pro or Thr-Pro motifs in proteins and contains a number of transcription factors as well as protein kinases in its catalog of known substrates.

    pdf15p fptmusic 11-04-2013 14 1   Download

  • Pharmacokinetics (t1/2) and the apparent volume of distribution Vapp (p. 28) by the equation: Vapp t1/2 = In 2 x –––– Cltot The smaller the volume of distribution or the larger the total clearance, the shorter is the half-life. In the case of drugs renally eliminated in unchanged form, the half-life of elimination can be calculated from the cumulative excretion in urine; the final total amount eliminated corresponds to the amount absorbed.

    pdf8p bigbaby87 04-09-2010 66 14   Download

  • Cancer Cell Biology The treatment of most human cancers with conventional cytoreductive agents has been unsuccessful due to the Gompertzian-like growth kinetics of solid tumors (i.e., tumor growth is exponential in small tumors, with increasing doubling times as tumors expand; since conventional chemotherapeutic agents target proliferating cells, noncycling cells in large tumors are relatively resistant). Genetic instability is inherent in most cancer cells and predisposes to the development of intrinsic and acquired drug resistance. Thus, although tumors arise from a single cell (i.e.

    pdf5p konheokonmummim 03-12-2010 57 4   Download

  • Highly active, small-molecule furin inhibitors are attractive drug candidates to fend off bacterial exotoxins and viral infection. Based on the 22-residue, active Lys fragment of the mung bean trypsin inhibitor, a series of furin inhibitors were designed and synthesized, and their inhibitory activity towards furin and kexin was evaluated using enzyme kinetic analysis.

    pdf8p inspiron33 25-03-2013 16 3   Download


Đồng bộ tài khoản