Electronics and computer science

In recent years, optical orthogonal frequency division multiplexing (OOFDM) has emerged as a dominant research and development area in the field of high-speed optical communications. OFDM is a potential candidate as the most promising next-generation optical networks such as passive optical networks and optical transport networks, due to their simple configuration based on low cost, high speed data rates, high spectral efficiency, high quality of service and robustness against narrow band interference, frequency selective fading, and chromatic dispersion.

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Jeffrey A Bailey*, Robert Baertsch†, W James Kent†, David Haussler‡ and Evan E Eichler* Addresses: *Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. †Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA. ‡Howard Hughes Medical Institute, 321 Baskin Engineering, University of California, Santa Cruz, CA 95064, USA. Correspondence: Evan E Eichler. E-mail: eee@cwru.

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Prediction of Saccharomyces cerevisiae replication origins Adam M Breier*, Sourav Chatterji† and Nicholas R Cozzarelli‡ Addresses: *Graduate Group in Biophysics, University of California-Berkeley, Berkeley, CA 94720-3204, USA. †Department of Computer Science, University of California-Berkeley, Berkeley, CA 94720-3204, USA. ‡Department of Molecular and Cellular Biology, Barker Hall, University of California-Berkeley, Berkeley, CA 94720-3204, USA. Correspondence: Nicholas R Cozzarelli. E-mail: ncozzare@socrates.berkeley.

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Opinion Predicting and validating microRNA targets Eric C Lai Address: 545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3200, USA. E-mail: lai@fruitfly.org comment Published: 31 August 2004 Genome Biology 2004, 5:115 The electronic version of this article is the complete one and can be found online at http://genomebiology.

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