Epigenetic chromatin

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  • Monoclonal antibodies (mAbs) are crucial in pharmaceutical biotechnology. Mammalian cell lines are the most preferred for their production. One of the significant challenging issues of mammalian expression systems is epigenetic gene silencing.

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  • Multicellular organisms comprise a variety of cell types that have the same genotype but distinct phenotypes. This diversity is possible because of the establishment of a specific epigenetic landscape that stabilizes gene expression profiles that are exclusive for a particular cell type.

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  • Does this mean that differences in genetic diversity levels will have predictable ecological consequences? The answer is no, because only one portion of genetic diversity is connected to ecological factors, i.e. adaptation. Ecological adaptation is a significant factor for example, in range expansion of plant species. Plants with different genotypes conferring the highest levels of fitness are expected to survive and reproduce better, shifting the gene pool over time towards higher frequencies of the alleles making up the more successful genotypes (Ward et al., 2008).

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  • Remaining Funds, which account for €147 billion of shares/units in issue, consist primarily of mixed funds, but also include real estate and other unclassified funds. This category has performed positively in Q1 2012, second only to equity funds in terms of revaluations, with asset growth of €8.9 billion or 6.4 per cent. Remaining funds were the strongest performing category in Q4 2011, and despite a continued resilient performance, the category attracted negligible net new investment of €0.1 billion. ...

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  • Hydrogen peroxide is a strong oxidant that can be injected into a contaminated zone to destroy petroleum contaminants. When injected to groundwater, hydrogen peroxide is unstable, and reacts with organic contaminants and subsurface materials. It decomposes to oxygen and water within hours of its introduction into groundwater generating heat in the process. Peroxide is typically shipped to a remediation site in liquid form at dose concentrations ranging from five percent to 50 percent by weight.

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  • Clients in the system specify an interest in the type of events that they are interested in. Some examples of interests specified by clients could be sports events or events sent to a certain discussion group. It is the system, which computes the clients that should receive a certain event. A particular event may thus be consumed by zero or more clients registered with the system. Events have explicit or implicit information pertaining to the clients which are interested in the event.

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  • Dynamicity of participants: Some P2P systems, such as [10], assume a fixed set of nodes in the system. However, one of the greatest potential strengths of P2P systems is when they eschew reliance on dedicated infrastructure and allow peers to leave the system at will. Even under these conditions, participants typically have broadly varying availability characteristics. Some peers are akin to servers: their membership in the system stays largely static. Others have much more dynamic membership, joining and leaving the system at will.

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  • Given that thinking steps have been shown to be modestly correlated with the efficiency of working memory (measured by digit span; see Devetag and Warglien, 2003) and aging may reduce working memory or, potentially, some other cognitive process related to strategic reasoning, these changes could lead older subjects to use lower values of n, and to choose higher numbers than younger subjects.

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  • Moreover, the concept of market segmentation is now becoming relevant in countries that have suffered from a lot of problems and shortages in the past, but are now ex- periencing an economic development equal to that of the western countries after World War II. In particular, due to the economic liberalization processes and the on- going opening of the Chinese economy for foreign trade and investment, which hav e been carried out since 19809 , this applies to the Peoples Republic of China.

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  • The private bond market remains much smaller than that for the government. The outstanding issuance of corporate bonds has risen to almost 10 percent of GDP in 2011, but the market is still very concentrated in short duration rates, with a limited investor base and less diversified issuers. This suggests that the private fixed income market is not a significant long-term financing source for non-financial corporations. Indexation: Around 90 percent of private bonds are linked to the DI rate, resulting in little incentive for active trading.

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  • Graphic design is a creative process that combines art and technology to communicate ideas in print and electronic media. Graphic design often refers to both the process (designing) by which the visual communication is created and the products (designs) which are generated. Common uses of graphic design include identity (logos and branding), websites, publications (magazines, newspapers, and books), advertisements, and product packaging.

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  • (BQ) Part 2 book "Handbook of vitamins" has contents: Pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, choline, vitamin - Dependent modifications of chromatin - Epigenetic events and genomic stability, dietary reference intakes for vitamins.

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  • Assume a policy with a $2 million premium that reimburses the policyholder when aggregate losses for the calendar year exceed $10 million. Assume that the losses covered by the policy are generally low severity/high frequency, with minimal catastrophe potential (i.e., the policy is meant to cover mostly pricing risk, not large loss risk). Also assume that the expected losses are $8 million, and that the expected losses normally occur evenly throughout the year. After one quarter, losses would have to be 500% of expected for attachment to occur.

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  • Intangible assets include goodwill arising from acquisitions made after January 1, 1992. Goodwill is amortized using the straight-line method over its estimated economic life, not to exceed forty years. Certain acquired intangible assets other than goodwill (‘in-process R&D') are expensed in the period of acquisition. Patents and trademarks acquired from third parties are capitalized and amortized over their remaining lifetime.

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  • The last two explanatory variables are control variables, while the remaining variables are the corporate governance variables that we discussed in Section VA. As discussed in Section II, the signs of most of these variables are empirical issues, so we use the observed signs to interpret our results. The top section of Table 7 shows estimates of four variants of equation (6) for the full sample.

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  • They were given titles only after a maquette (at leas) had been made. In some cases the work had already been put together as a full-scale mockup or fabricated in steel before its image became clear and it was named. Occasionally titles ...came to me all at once. Moses is an instance of the latter. The parallel uprights suggested the horns in Michelangelo’s Moses.

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  • Typically the processes are adapted from wood processing which benefit from the larger mill size (Paper I). However, concerns associated with the local availability of non-wood raw material force pulp mills to remain small and thus lead to the need for processes to be as simple as possible in order to be competitive unless very valuable by-products can also be extracted. The benefits of utilising agro-fibres are their generally lower lignin content compared with woods (Grant 1958, Hurter 1988).

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  • Minimum temperatures in winter are very likely to increase more than the mean winter temperature in northern Europe (Hanssen-Bauer et al., 2005), while maximum temperatures in summer are likely to increase more than the mean summer temperature in southern and central Europe (Tebaldi et al., 2006). Concerning precipitation, the annual sum is very likely to increase in northern Europe (Hanssen-Bauer et al., 2005) and decrease in the Mediterranean area.

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  • These guidelines specify standard appraisal procedures for Japanese real estate appraisers (the only profession that is licensed and registered by the government by law. Hereinafter “Japanese Appraisers”) to appraise overseas real estate for investment purposes. As the globalization of the real estate market progresses, cross-border real estate investment is gaining momentum. In addition, real estate investment trust (REIT) markets have been set up in the past few years, and international competition in real estate markets is heightening rapidly....

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  • The success of MIPIM Asia’s sixth edition last year confi rmed the dynamism of the Asian property market and the fact that the show is now the international event for major real estate companies operating within the region or seeking to work internationally with Asia Pacifi c players. The emerging presence of retailers refl ected Asia Pacifi c’s potential for retail expansions and the attractiveness of retail real estate.

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