Epigenetic regulation

Xem 1-20 trên 88 kết quả Epigenetic regulation
  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Epigenetic regulation: DNA confers identity but is not enough to maintain it...

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  • For decades, endocytosis has been recognized as a fundamental cellular process that regulates the uptake of small molecules (cell surface proteins, bacteria, toxins, etc.) into the cell. So why, after years of study, does this simple process warrant more discussion? Anyone who has examined the endocytic pathway will appreciate that this conceptually simple mechanism is highly complex and sophisticated. Like ballet dancers who make their synchronous performance seem effortless, the cell brings in molecules via a carefully choreographed mechanism.

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  • MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene expression post-transcriptionally. Recent studies have demon-strated that epigenetic mechanisms, including DNA methylation and his-tone modification, not only regulate the expression of protein-encoding genes, but also miRNAs, such as let-7a, miR-9, miR-34a, miR-124, miR-137, miR-148 and miR-203.

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  • Chapter 16 - Gene regulation in eukaryotes. The main contents of this chapter include all of the following: Overview of eukaryotic gene regulation, control of transcription initiation, chromatin structure and epigenetic effects, regulation after transcription, a comprehensive example: sex determination in Drosophila.

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  • MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis.

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  • (BQ) Part 1 book "Epigenetics and dermatology" presents the following contents: Introduction to epigenetics, laboratory methods in epigenetics, epigenetics and fibrosis, epigenetic modulation of hair follicle stem cells, epigenetics and the regulation of inflammation,...

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  • There is growing evidence on the importance of studies focusing on mechanisms and strategies leading to cancer prevention. The plethora of approaches include regulation of oxidative stress using antioxidant therapies, carefully balanced diets and living habits, epidemiological evidence and molecular approaches on the role of key biological molecules such as antioxidant enzymes, vitamins, proteins and naturally occurring free radical scavengers as well as controversial results and clinical applications. These are some of the topics that this book highlights.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Advances in the genetics and epigenetics of gene regulation and human disease...

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  • Histone acetylation plays an integral role in the epigenetic regulation of gene expression. Transcriptional activity reflects the recruitment of oppo-sing classes of enzymes to promoter elements; histone acetyltransferases (EC that deposit acetyl marks at a subset of histone residues and histone deacetylases that remove them.

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  • The folding of eukaryotic DNA into the 30 nm fibre comprises the first level of transcriptionally dormant chromatin. Understanding its structure and the processes of its folding and unfolding is a prerequisite for under-standing the epigenetic regulation in cell differentiation.

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  • During the development of multicellular organisms, both transient and stable gene expression patterns have to be established in a precisely orchestrated sequence. Evidence from diverse model organisms indicates that this epigenetic program involves not only transcription factors, but also the local structure, composition, and modification of chromatin, which define and maintain the accessibility and transcriptional competence of the nucleosomal DNA template.

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  • After recent accounting scandals in once high-flying firms like Enron and WorldCom, man- agement behavior has been under close scrutiny by regulators, financial media, and researchers. Jensen (2005) argues that the dramatic increase in corporate scandals around the turn of the cen- tury can be explained by agency costs of overvalued equity: when a firm’s equity is substantially overvalued, managers are forced to take value-destroying actions (some perhaps fraudulent) to satisfy the market’s unrealistic growth expectations.

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  • The transcription factor ZBP-89 has been implicated in the induction of growth arrest and apoptosis. In this article, we demonstrate that ZBP-89 was able to restrain senescence in NCI-H460 human lung cancer cells, through epigenetically regulating p16 INK4a expression.

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  • Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA methylation is an evolutionally con-served mechanism to regulate gene expression in mammals.

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  • DNA promoter methylation, a main way of epigenetic regulation, has been studied for detection, prognosis and treatment of breast cancer. In this study, methylation specific polymerase chain reaction (MSP) was used to analyze the promoter methylation of 2 tumor suppressor genes BRCA1 and RASSF1A in tumor and paired adjacent normal tissues of 76 Vietnamese breast cancer patients.

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  • Cancer may constitute the most extensively studied disease entity of our time. Nevertheless, our comprehension of the cellular and molecular pathology of malignant transformation is incomplete. In view of the diverse clinical presentations of various malignancies, doubts may be raised as to whether it is appropriate to refer to cancer as one group of disease states. The notion of malignant tumors as a pathologic and pathophysiologic class of conditions begs the question for defining criteria that characterize all malignant growths, regardless of their tissue of origin....

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  • With complaints and inquiries from senior citizen investors concerning financial services and investment fraud increasing, the Missouri Securities Division, a division in the Office of Missouri Secretary of State Robin Carnahan, 1 took steps to determine how to best increase protection for those investors.

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  • Does this mean that differences in genetic diversity levels will have predictable ecological consequences? The answer is no, because only one portion of genetic diversity is connected to ecological factors, i.e. adaptation. Ecological adaptation is a significant factor for example, in range expansion of plant species. Plants with different genotypes conferring the highest levels of fitness are expected to survive and reproduce better, shifting the gene pool over time towards higher frequencies of the alleles making up the more successful genotypes (Ward et al., 2008).

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