Evolution and genetics

The case of homologous monomeric c-type and oligomeric b-type crystallins has been described and analyzed in evolutionary terms. Data and hypotheses from molecular genetics and structural investigations converge and suggest a novel three-phase model for the evolutionary history of crystallin-type proteins. In the divergent cascades of monomeric and oligomeric crystallins, a pivotal role was played by alterations in the gene segments encoding the C-terminal extensions and the intermotif or interdomain linker peptides.

9p system191 01-06-2013 41 4   Download

Murine double minute 2 (MDM2) protein exhibits many diverse biochemi-cal functions on the tumour suppressor protein p53, including transcrip-tional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit ATP-dependent molecular chap-erone activity and directly mediate folding of the p53 tetramer. Analysing the ATP-dependent function of MDM2 will provide novel insights into the evolution and function of the protein.

12p research12 29-04-2013 61 4   Download

The (ba)8-barrel is the most common enzyme fold and it is capable of cata-lyzing an enormous diversity of reactions. It follows that this scaffold should be an ideal starting point for engineering novel enzymes by directed evolution. However, experiments to date have utilized in vivo screens or selections and the compatibility of (ba)8-barrels with in vitro selection methods remains largely untested.

14p fptmusic 11-04-2013 41 3   Download

L-Arabinitol 4-dehydrogenase (Lad1) of the cellulolytic and hemicellulolytic fungusHypocrea jecorina(anamorph: Trichoderma reesei) has been implicated in the catabolism ofL-arabinose, and genetic evidence also shows that it is involved in the catabolism of D-xylose in xylitol dehydrogenase (xdh1) mutants and of D-galactose in galactokinase (gal1) mutants of H. jecorina.In order to identify the substrate specificity of Lad1, we have recombinantly produced the enzyme inEscherichia coliand purified it to physical homogeneity....

9p dell39 03-04-2013 31 3   Download

Patterns of protein interactions are organized around complex heterogene-ous networks. Their architecture has been suggested to be of relevance in understanding the interactome and its functional organization, which per-vades cellular robustness. Transcription factors are particularly relevant in this context, given their central role in gene regulation.

12p dell39 27-03-2013 39 3   Download

Crustacean hyperglycemic hormone (CHH) and vitellogenesis-inhibiting hormone (VIH), produced by the X organ–sinus gland neurosecretory com-plex, belong to a peptide group referred to as the CHH family, which is widely distributed in arthropods. In this study, genetic variants and post-translationally modified isoforms of CHH and VIH were characterized in the European lobster Homarus gammarus.

10p inspiron33 26-03-2013 51 4   Download

It is widely accepted that chloroplasts derived from an endosymbiotic event in which an early eukaryotic cell engulfed an ancient cyanobacterial pro-karyote. During subsequent evolution, this new organelle lost its autonomy by transferring most of its genetic information to the host cell nucleus and therefore became dependent on protein import from the cytoplasm.

11p vinaphone15 27-02-2013 39 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years

10p dauphong3 26-12-2011 48 5   Download

*Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, UK. †Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK. ‡Current address: Program in Genetics and Genomic Biology, Hospital for Sick Children, University Avenue, Toronto, Ontario M5G 1X8, Canada. §Current address: Facultad de Química, Cátedra de Inmunología, Universita de la Republica, Montevideo 11300, Uruguay. Correspondence: Rick M Maizels. E-mail: rick.maizels@ed.ac.

0p thulanh21 15-11-2011 57 3   Download

Jeffrey A Bailey*, Robert Baertsch†, W James Kent†, David Haussler‡ and Evan E Eichler* Addresses: *Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. †Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA. ‡Howard Hughes Medical Institute, 321 Baskin Engineering, University of California, Santa Cruz, CA 95064, USA. Correspondence: Evan E Eichler. E-mail: eee@cwru.

0p thulanh21 15-11-2011 47 2   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Lack of congruence between morphometric evolution and genetic differentiation suggests a recent dispersal and local habitat adaptation of the Madeiran lizard Lacerta dugesii

0p toshiba19 15-11-2011 38 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of genetic systems using experimental evolution and whole-genome sequencing...

5p thulanh20 10-11-2011 42 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example...

9p toshiba15 25-10-2011 47 3   Download