Genetic determinants

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  • Human genetics is the medical field with the most rapid and, one can say, overwhelming progress. The medical practitioner constantly needs to be up-to-date on the newest developments in his field. The diversity and rapid dynamics of advancements in genetics can sometimes overcome the assimilation possibilities of one person; thus, overspecialization for narrowing and deepening the research focus is needed. Consequently, expert opinion is much valued. This book aims to provide exactly such opinions regarding several genetic diseases.

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  • Tuyển tập các báo cáo nghiên cứu về lâm nghiệp được đăng trên tạp chí lâm nghiệp quốc tế đề tài: Genetic determination of vessel area in oak (Quercus robur L and Q petraea Liebl): a characteristic related to the occurrence of stem shakes...

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  • Tuyển tập các báo cáo nghiên cứu về lâm nghiệp được đăng trên tạp chí lâm nghiệp quốc tế đề tài: The influences of age, extractive content and soil water on wood color in oak: the possible genetic determination of wood color...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II

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  • Tham khảo sách 'genetic disorders', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genetic determinants of phenotypic diversity in humans...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed

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  • The aim of the present study was to determine the phenotypic resistance pattern to βlactam antibiotics among Escherichia coli clinical isolates and to identify the genetic determinants responsible for β-lactam antibiotic resistance. Forty Escherichia coli isolates were included in this study. Identification of tested strains was confirmed using MALDITOF/MS. Phenotypic and genotypic β-lactamase patterns were investigated.

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  • Many disorders exhibit the feature of locus heterogeneity, which refers to the fact that mutations in different genes can cause phenotypically similar disorders. For example, osteogenesis imperfecta (Chap. 357), long QT syndrome (Chap. 226), muscular dystrophy (Chap. 382), homocystinuria (Chap. 358), retinitis pigmentosa (Chap. 29), and hereditary predisposition to colon cancer (Chap. 87) or breast cancer (Chap. 86) can each be caused by mutations in distinct genes.

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  • Over the last 20 years the development and application of genetics has revolutionized forensic science. In 1984, the analysis of polymorphic regions of DNA produced what was termed ‘a DNA fingerprint’ [1]. The following year, at the request of the United Kingdom Home Office, DNA profiling was successfully applied to a real case, when it was used to resolve an immigration dispute [2]. Following on from this, in 1986, DNA evidence was used for the first time in a criminal case and identified Colin Pitchfork as the killer of two school girls in Leicestershire, UK.

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  • Even though the Committee is not currently proposing mandatory capital charges specifically for interest rate risk in the banking book, all banks must have enough capital to support the risks they incur, including those arising from interest rate risk. If supervisors determine that a bank has insufficient capital to support its interest rate risk, they must require either a reduction in the risk or an increase in the capital held to support it, or a combination of both.

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  • I wrote the first edition of this book more than 20 years ago, and the discoveries in genetics since then have been phenomenal. The new knowledge and applications of human genetics to health and to society have made it even more necessary that nurses "think genetically" in their practice and, indeed in their lives. Genetic factors can be responsible in some way for both direct and indirect disease causation; for variation that determines predisposition, susceptibility, and resistance to disease and also for response to therapeutic management.

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  • The Human DNA Sequence The complete DNA sequence of each chromosome provides the highest resolution physical map. The primary focus of the HGP was to obtain DNA sequence for the entire human genome as well as model organisms. Although the prospect of determining the complete sequence of the human genome seemed daunting several years ago, technical advances in DNA sequencing and bioinformatics led to the completion of a draft human sequence in June 2000, well in advance of the original goal year of 2003.

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  • Complex Genetic Disorders The expression of many common diseases such as cardiovascular disease, hypertension, diabetes, asthma, psychiatric disorders, and certain cancers is determined by a combination of genetic background, environmental factors, and lifestyle. A trait is called polygenic if multiple genes contribute to the phenotype or multifactorial if multiple genes are assumed to interact with environmental factors. Genetic models for these complex traits need to account for genetic heterogeneity and interactions with other genes and the environment.

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  • Population Genetics In population genetics, the focus changes from alterations in an individual's genome to the distribution pattern of different genotypes in the population. In a case where there are only two alleles, A and a, the frequency of the genotypes will be p2 + 2pq + q2 = 1, with p2 corresponding to the frequency of AA, 2pq to the frequency of Aa, and q2 to aa. When the frequency of an allele is known, the frequency of the genotype can be calculated. Alternatively, one can determine an allele frequency, if the genotype frequency has been determined. Allele frequencies vary...

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  • Control analysis of the glycolytic flux was carried out in two fast-growth tumor cell types of human and rodent origin (HeLa and AS-30D, respect-ively). Determination of the maximal velocity (Vmax) of the 10 glycolytic enzymes from hexokinase to lactate dehydrogenase revealed that hexokin-ase (153–306 times) and phosphfructokinase-1 (PFK-1) (22–56 times) had higher over-expression in rat AS-30D hepatoma cells than in normal freshly isolated rat hepatocytes.

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  • The structure of human telomeric DNA is controversial; it depends upon the sequence contexts and the methodologies used to determine it. The solution structure in the presence of K + is particularly interesting, but the structure is yet to be elucidated, due to possible conformational heterogen-eity.

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  • Chapter 16 - Gene regulation in eukaryotes. The main contents of this chapter include all of the following: Overview of eukaryotic gene regulation, control of transcription initiation, chromatin structure and epigenetic effects, regulation after transcription, a comprehensive example: sex determination in Drosophila.

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  • This study aimed to construct phylogenetic trees to subspecies of swiftlet, thereby detecting and determining the phylogenetic relationships of swiftlet populations in geographical areas in Vietnam, provide the data for the conservation, sustainable exploitation of the bird nest resources.

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