Genetic structure

The article develops a novel framework for Multidisciplinary Design Optimization of aircraft wing. Practically, the study implements a high-fidelity fluid/structure analyses and accurate optimization codes to obtain the wing with best performance.

14p vifilm 24-09-2024 1 1   Download

The study "Multi-objective solar building envelope design optimization" includes four main objectives: 1 - To explore the components of a building envelope design optimization framework that would be developed for the conceptual building design phase; 2 - To establish an optimization process for different BIPV application types; 3 - To investigate the optimization algorithms and methods that could be used to optimize building envelope design for BIPV; 4 - To develop and validate an optimization framework to integrate BIPV into the building structure.

158p runthenight04 02-02-2023 5 2   Download

Research purposes: To define cause-effect relationship of genetic phenomena in living organisms, to determine the structure of cognitive competence on genetic phenomena, thereby to apply cause-effect relationship on teaching genetics to develop cognitive competence on the regularity of genetic phenomena for students, contributing to improving the quality of acquiring knowledge of this subject.

27p tunelove 10-06-2021 24 3   Download

Research purpose: Determine the composition, structure of mitochondrial genome, compare the difference in sequence, identify specific genetic characteristics of the six indigenous pig breeds, thereby contributing to the database to identification and conservation.

27p extraenglish 24-05-2021 22 4   Download

Collecting complete data of mitochondrial genome of 6 indigenous pig breeds in Vietnam (I, Mong Cai, Muong Lay, Huong, Muong Khuong and Ha Lang pigs) and deposited on the Genebank; determine the composition, structure of mitochondrial genome, compare the difference in sequence, identify specific genetic characteristics of the six indigenous pig breeds, thereby contributing to the database to identification and conservation.

27p capheviahe26 25-01-2021 14 4   Download

The main purpose of the study was to determine the adoption of selected ecological agricultural practices by the farmers and the factors influencing the adoption in district Kanpur Dehat. Two blocks were selected randomly from the district and three villages were selected on random basis from each block, thus a total of six villages were selected from two blocks, 20 respondents were randomly selected from each village thus a total of 120 respondents in total were interviewed on a structural schedule.

8p gaocaolon9 22-12-2020 12 2   Download

The present investigation was under taken with the objectives to estimate genetic variability, heritability and genetic advance for yield and yield contributing components of cucumber. The experimental materials for this investigation were fourteen genotypes of cucumber consisting of parthenocarpic, gynoecious and monecious germplasms crossed in line × tester mating design produced thirty three hybrids (F1). Thirty three F1 crosses along with their parents were evaluated in two environments viz.

9p angicungduoc6 22-07-2020 20 2   Download

Cycads occur in lowland forests and are threatened by their degradation, fragmentation and over-exploitation. Our results indicate that cycad population sizes were very small (less 100 individuals) with high propagules. These increased mating between closely related individuals growing in clumps. The allozyme data show although all studied cycads maintained high levels of genetic diversity, an average of 0.556 (0.491 in C. hoabinhensis to 0.598 in C. chevalieri ), the degree of inbreeding was high.

10p 12120609 01-06-2020 16 3   Download

Hybridization of species with porous genomes can eventually lead to introgression via repeated backcrossing. The potential for introgression between species is reflected by the extent of segregation distortion in later generation hybrids.

12p vishikamaru2711 29-04-2020 18 2   Download

A database consisting of 23 tripeptides was used to study the quantitative relationships between electric surface potential descriptors and antioxidant activity QESARs. The important structural descriptors SaaNH_acnt, SsOH_acnt, SaaN, SaaN_acnt, SsssCH, SaaaC, SsNH3p, SdO, SdO_acnt were selected for constructing the linear models QESARs with genetic algorithm. The best 4-variable linear model QESARlinear including the structural descriptors SaaN, SdO, SdO_acnt and SsOH_acnt was constructed. The quality QESARlinear was exhibited in statistical values R2 fitness of 97.

7p nguathienthan1 20-11-2019 11 2   Download

Before we begin to study in detail the structure and activities of genes, and the experimental evidence underlying those concepts, we need a fuller outline of the adventure that lies before us. Thus, in this chapter and in chapter 3, we will fl esh out the brief history of molecular biology presented in chapter 1. In this chapter we will begin this task by considering the behavior of genes as molecules.

37p tangtuy05 30-03-2016 67 3   Download

The human b-globin gene locus is the subject of intense study, and over the past two decades a wealth of information has accumulated on how tissue-specific and stage-specific expression of its genes is achieved. The data are extensive and it would be difficult, if not impossible, to formulate a comprehensive model integrating every aspect of what is currently known. In this review, we introduce the fundamental characteristics of globin locus regulation as well as questions on which much of the current research is predicated.

11p system191 01-06-2013 47 4   Download

In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high affinity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was significantly enhanced by Zn2+, an effect possibly mediated through Cys-rich zinc finger-like sequences on laminin....

8p system191 01-06-2013 41 4   Download

The design of b-glycosidases with planed substrate specificity for biotechnological application has received little attention. This is mostly a consequence of the lack of data on the molecular basis of the b-glycosidase specificity, namely data on the energy of the noncovalent interactions in the enzymetransition state complex. In an attempt to fill this gap, sitedirected mutagenesis and enzyme steady-state kinetic experiments with different substrates were conducted, using as model a digestive b-glycosidase (glycoside hydrolase family 1) from Spodoptera frugiperda (Lepidoptera) (Sfbgly50).

10p system191 01-06-2013 39 4   Download

A recombinant lipase cloned from Pseudomonas fragi strain IFO 3458 (PFL) was found to retain significant activity at low temperature. In an attempt to elucidate the structural basis of this behaviour, a model of its three-dimensional structure was built by homology and compared with homologous mesophilic lipases, i.e. the Pseudomonas aeruginosa lipase (45% sequence identity) and Burkholderia cepacia lipase (38%).

8p system191 01-06-2013 48 4   Download

The case of homologous monomeric c-type and oligomeric b-type crystallins has been described and analyzed in evolutionary terms. Data and hypotheses from molecular genetics and structural investigations converge and suggest a novel three-phase model for the evolutionary history of crystallin-type proteins. In the divergent cascades of monomeric and oligomeric crystallins, a pivotal role was played by alterations in the gene segments encoding the C-terminal extensions and the intermotif or interdomain linker peptides.

9p system191 01-06-2013 41 4   Download

The insect ecdysteroid receptor consists of a heterodimer between EcR and the RXR-orthologue, USP. We addressed the question of whether this heterodimer, like all other RXR heterodimers, may be formed in the absence of ligand and whether ligand promotes dimerization. We found that C-terminal protein fragments that comprised the ligand binding, but not the DNA binding domain of EcR and USP and which were equipped with the activation or DNA binding region of GAL4, respectively, exhibit a weak ability to interact spontaneously with each other.

9p system191 01-06-2013 29 3   Download

SHP-1, a protein-tyrosine phosphatase with two srchomology 2 domains, is expressed predominantly in hematopoietic and epithelial cells and has been implicated in numerous signaling pathways as a negative regulator. Two promoters direct the expression of human and murine SHP-1, and two types of transcripts (I) and (II) SHP-1, are initiated from each of these promoters. The cDNA sequences of (I)SHP-1 and (II)SHP-1 are identical except in the 5¢ untranslated region and in the first few coding nucleotides.

8p system191 01-06-2013 35 3   Download

Introducing site-directed mutations in surface-exposed residues of subunit II of the heme aa3 cytochrome c oxidase of Paracoccus denitrificans, we analyze the kinetic parameters of electron transfer from reduced horse heart cytochrome c. Specifically we address the following issues: (a) which residues on oxidase contribute to the docking site for cytochrome c, (b) is an aromatic side chain required for electron entry from cytochrome c, and (c) what is the molecular basis for the previously observed biphasic reaction kinetics....

9p system191 01-06-2013 36 3   Download

Division of Medicinal and Natural Products Chemistry, Department of Chemistry and Department of Chemical Engineering, University of Iowa, USA; 2Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark Synthetic peptides based on amino-acid residues 27–38 of human serum amyloid P component represent a novel type of heparin binders as they do not contain clusters of basic amino acids or other known features associated with protein or peptide heparin binding.

8p system191 01-06-2013 53 4   Download