Helicobacter pylori isolates

The rate of antibiotic resistance in Helicobacter pylori (H.pylori) is increasing in Vietnam in recent years and has become a main challenge in the management of H. pylori infection. Data about the resistance remains different depending on the time, demography and especially the methods of determining the antibiotics susceptibility. To determine the antibiogram of H.pylori strains isolated from a population in Central Vietnam to clarithromycin, levofloxacin by E-test and disk diffusion, compare two diffusion methods.

7p vifaye 20-09-2024 2 1   Download

In this study, we assessed the status of antibiotic resistance of H. pylori isolates to antimicrobial agents at Hospital of Hue University of Medicine and Pharmacy in Central Vietnam and identified the underlying molecular mechanisms related to tetracycline and amoxicillin resistance.

8p vifaye 20-09-2024 4 1   Download

Catalytic antibodies capable of digesting crucial proteins of pathogenic bac-teria have long been sought for potential therapeutic use. Helicobacter pyloriurease plays a crucial role for the survival of this bacterium in the highly acidic conditions of human stomach. The HpU-9 monoclonal anti-body (mAb) raised againstH. pyloriurease recognized thea-subunit of the urease, but only slightly recognized theb-subunit. However, when isolated both the light and the heavy chains of this antibody were mostly bound to the b-subunit....

9p fptmusic 11-04-2013 45 3   Download

Metronidazole (MTZ) is widely used in combination therapies against the human gastric pathogenHelicobacter pylori. Resistance to this drug is com-mon among clinical isolates and results from loss-of-function mutations in rdxA, which encodes an oxygen-insensitive nitroreductase. The RdxA-associated MTZ-reductase activity ofH. pyloriis lost upon cell disruption. Here we provide a mechanistic explanation for this phenomenon.

11p viettel02 22-02-2013 47 3   Download