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Hematopoietic stem cell transplantation

Xem 1-20 trên 21 kết quả Hematopoietic stem cell transplantation
  • Severe graft-versus-host disease (GvHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Bone marrow mesenchymal stem cells (BM-MSCs) display immunosuppressive activity and have been previously shown to improve the outcome of GvHD therapy.

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  • Excess Capacity of Hematopoietic Stem Cells In the absence of disease, one never runs out of hematopoietic stem cells. Indeed, serial transplantation studies in mice suggest that sufficient stem cells are present to reconstitute several animals in succession, with each animal having normal blood cell production. The fact that allogeneic stem cell transplant recipients also never run out of blood cells in their life span, which can extend for decades, argues that even the limiting numbers of stem cells provided to them are sufficient.

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  • This book documents the increased number of stem cell related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hematopoietic stem cell transplantation for systemic lupus erythematosus...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Function, Adjustment, Quality of Life and Symptoms (FAQS) in Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Survivors: A Study Protocol

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study...

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  • Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already part of established medical practice. Hematopoietic stem cells (HSCs) (Chap. 68) are responsible for the long-term repopulation of all blood elements in bone marrow transplant recipients. HSC transplantation is now the gold standard against which other stem cell transplantation therapies will be measured. Transplantation of differentiated cells is also a clinical reality, as donated organs (e.g., liver, kidney) and tissues (i.e.

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  • Harrison's Internal Medicine Chapter Transplantation 108. Hematopoietic Cell Hematopoietic Cell Transplantation: Introduction Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells, but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells, hematopoietic cell transplantation has become the preferred generic term for this process.

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  • Graft Failure While complete and sustained engraftment is usually seen posttransplant, occasionally marrow function either does not return or, after a brief period of engraftment, is lost. Graft failure after autologous transplantation can be the result of inadequate numbers of stem cells being transplanted, damage during ex vivo treatment or storage, or exposure of the patient to myelotoxic agents posttransplant. Infections with cytomegalovirus (CMV) or human herpes virus type 6 have also been associated with loss of marrow function.

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  • Pneumocystis jiroveci pneumonia, once seen in 5–10% of patients, can be prevented by treating patients with oral trimethoprim-sulfamethoxazole for 1 week pretransplant and resuming the treatment once patients have engrafted. The risk of infection diminishes considerably beyond 3 months after transplant unless chronic Most GVHD transplant develops, centers requiring recommend continuous continuing immunosuppression. trimethoprim-sulfamethoxazole prophylaxis while patients are receiving any immunosuppressive drugs and also recommend careful monitoring for late CMV reactivation.

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  • Bacterial Infections In the first month after hematopoietic stem cell transplantation, infectious complications are similar to those in granulocytopenic patients receiving chemotherapy for acute leukemia (Chap. 82). Because of the anticipated 1- to 3week duration of neutropenia and the high rate of bacterial infection in this population, many centers give prophylactic antibiotics to patients upon initiation of myeloablative therapy. Quinolones decrease the incidence of gram-negative bacteremia among these patients.

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  • Graft-versus-Host Disease GVHD is the result of allogeneic T cells that were either transferred with the donor's stem cell inoculum or develop from it, reacting with antigenic targets on host cells. GVHD developing within the first 3 months posttransplant is termed acute GVHD, while GVHD developing or persisting beyond 3 months posttransplant is termed chronic GVHD.

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  • PCR can be used to monitor EBV production after hematopoietic stem cell transplantation. High or increasing viral loads predict an enhanced likelihood of developing EBV-LPD and should prompt rapid reduction of immunosuppression and search for a focus of disease. If reduction of immunosuppression does not have the desired effect, administration of a monoclonal antibody to CD20 (rituximab or others) for the treatment of B cell lymphomas that express this surface protein has elicited dramatic responses and currently constitutes first-line therapy for CD20-positive EBV-LPD.

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  • Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells, but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells, hematopoietic cell transplantation has become the preferred generic term for this process.

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  • For recipients of allogeneic hematopoietic stem cell transplantation (HSCT), Mycobacterium tuberculosis may act as a signi¢cant opportunistic pathogen in the early posttransplantation period, especially in areas where tuberculosis (TB) is endemic.

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  • Hematopoietic Stem Cell Transplantation This is the best therapy for the young patient with a fully histocompatible sibling donor (Chap. 108). Human leukocyte antigen (HLA) typing should be ordered as soon as the diagnosis of aplastic anemia is established in a child or younger adult. In transplant candidates, transfusion of blood from family members should be avoided so as to prevent sensitization to histocompatibility antigens; while transfusions in general should be minimized, limited numbers of blood products probably do not seriously affect outcome.

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  • The third section of this book is ‘Adeno-associated-virus Vector’. Chapter nine by Sun et al. introduces the adeno-associated virus (AAV) mediated β-thalassemia gene therapy. Human hematopoietic stem cells (HSCs) were obtained from β-thalassemia patients, transfected with the recombinant AAV containing β-globin gene. The transfected cells were then transplanted into Nude/SCID mice, and the long term expression of β-globin in vivo was examined. In the tenth chapter, Korecka et al. compare AAV serotypes for gene delivery to dopaminergic neurons in the substantia nigra (SN)....

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  • Adenoviruses have been recognized as opportunistic and significant viral pathogens in immunocompromised patients such as recipients of hematopoietic stem cells or other solid organs treated with immunosuppressive agents, and among patients with acquired immunodeficiency syndrome. These patients are incapable of developing a normal immune response. Reactivation of adenoviruses in the impaired immunological response leads to acute or persistent infections with high morbidity or even mortality in these patients.

    pdf416p ti_du_hoang 27-08-2012 45 7   Download

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