Hepatitis c treatment

In particular, the IL28B gene polymorphisms have been studied and shown to have impacts on drug responses in the treatment of many diseases, such as chronic hepatitis C, chronic hepatitis B, and myeloproliferative neoplasms.

14p meyerowitz 25-12-2021 9 0   Download

An unexpected recurrence of hepatocellular carcinoma (HCC) sometimes occurs in patients with hepatitis C virus (HCV) after treatment with direct-acting antivirals (DAAs). However, the characteristics of patients with HCC recurrence may differ depending on time after DAA treatment. We aimed to identify risk factors related to HCC recurrence according to time after DAA treatment.

12p vimahuateng 26-11-2021 6 0   Download

Clinopodium gracile (Benth.) Matsum (C. gracile) is an annual herb with pharmacological properties effective in the treatment of various diseases, including hepatic carcinoma. Triterpenoid saponins are crucial bioactive compounds in C. gracile. However, the molecular understanding of the triterpenoid saponin biosynthesis pathway remains unclear.

16p vijeeni2711 24-07-2021 10 0   Download

The aim of this study was to investigate the mutational diversity of HCV core and NS5A regions and variation ofIL28B gene to predict virological response. Thirty HCV patients were included in this study.

17p chauchaungayxua8 03-10-2020 8 1   Download

The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little has been documented about the mechanism by which peretinoin exerts its inhibitory effects against recurrent HCC in humans in vivo.

13p vijennie2711 29-09-2020 12 1   Download

Hepatitis C treatment is currently facing many challenges, such as high costs of medicines, side effects in patients, and low success rates with Hepatitis C Virus genotype 1b (HCV-1b). In order to identify what characteristics of HCV-1b cause drug resistance, many sequence analysis methods are conducted, and bio-markers helping to predict failure rates are also proposed. However, the results may be imprecise when these methods work with a dataset having a small number of labeled sequences and short length sequences.

11p caygaocaolon6 22-07-2020 8 0   Download

Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak®) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are indicated in the treatment of HCV in patients with genotype 1 infection.

8p vijiraiya2711 27-05-2020 10 0   Download

Transplantation of hepatitis C virus (HCV)-positive organs has undergone a paradigm shift because of the advent of direct-acting antivirals. We present the case of a 57-year-old man successfully treated initially with pegylated interferon and ribavirin after HCV recurrence postliver transplantation. He subsequently developed end-stage renal disease and received a genotype 1a HCV-positive kidney transplant. A 12-week course of ledipasvir/sofosbuvir and low-dose ribavirin was initiated and sustained virologic response was achieved.

3p covid19 11-05-2020 14 0   Download

Thalassemia is an autosomal recessive disease causing haemolytic anaemia. The ideal treatment of these patients involves regular, 2-4 weekly blood transfusions. The major complications by this treatment are the transmission of transfusion acquired infections such as Hepatitis B virus infection, Hepatitis C virus infection, Human immunodeficiency virus infection, Syphilis, Malaria and transfusion acquired iron overload.

5p kequaidan4 05-05-2020 7 1   Download

Despite recent development of direct acting antivirals for treatment of hepatitis C, the current standard of care may still include pegylated-interferon, which is associated with frequent and, at times, serious adverse events.

3p vienzym2711 03-04-2020 5 0   Download

This study is a cross-sectional study aimed to assess the rate of occurrence of secondary occult hepatitis C virus (HCV) infection in patients treated with the combination of sofosbuvir and daclatasvir. This study included 40 patients whose serum turned negative for HCV ribonucleic acid (HCV RNA) via real time polymerase chain reaction (RT-PCR) after 3 months of the treatment. Blood samples on EDTA were collected from the patients to detect HCV RNA in peripheral blood mononuclear cells (PBMCs).

9p trinhthamhodang4 22-03-2020 8 0   Download

Abatacept is increasingly used for rheumatoid arthritis (RA) and juvenile idiophathic arthritis (JIA) treatment. However little is known about the risk of hepatotoxicity. The aim of this study was to determine whether the inhibition of the T cell CD28 receptor by abatacept results in acute hepatitis in BALB/c mice.

6p vimax2711 27-03-2020 9 0   Download

The epidemiology of viral hepatitis and syphilis in antenatal patient is of paramount importance for health planner and program managers. This study was conducted to assess to know the seroprevalnce of Hepatitis B Hepatitis C and syphilis in antenatal patient and to re-evaluate the need for routine antenatal care screening. All samples were tested to detect HbsAg by enzyme linked immunosorbent assay (ELISA), anti HCV antibody by ELISA and antibodies to Treponema palladium by qualitative Rapid Plasma Regain (RPR). Total 1000 samples were tested.

6p caygaocaolon3 27-02-2020 32 0   Download

The main aim of this study is to critically investigate in current up-to-date the technology of rDNA and its biomedical applications as therapeutic proteins. rDNA is the new technology and is a field of molecular biology where scientist reshape the DNA to form synthetic molecular that help to cure many diseases related to human being. A therapeutic proteins are proteins engineered in laboratory for pharmaceutical purpose, making of insulin is one of the most important benefits ever could be achieved by this technology.

9p nguaconbaynhay3 07-02-2020 7 0   Download

Direct-acting antiviral agents against HCV with or without peginterferon plus ribavirin result in higher eradication rates of HCV and shorter treatment duration. We examined which is better for predicting persistent virologic response, the assessment of serum HCV RNA at 12 or 24 weeks after the end of treatment for predicting sustained virologic response (SVR12 or SVR24, respectively) in patients treated by HCV NS3/4A protease inhibitors with peginterferon plus ribavirin.

6p viwashington2711 04-12-2019 25 0   Download

All-oral combination of direct-acting antivirals could lead to higher sustained virologic response (SVR) in hepatitis C virus (HCV)-infected patients. In the present study, we examined the efficacy and safety of the dual oral treatment with HCV nonstructural protein (NS) 5A inhibitor daclatasvir (DCV) plus HCV NS3/4A inhibitor asunaprevir (ASV) for 24 weeks in real-world HCV genotype 1-infected Japanese individuals.

6p viwashington2711 04-12-2019 7 0   Download

The only hope for effective treatment of liver cancer lies in early detection or screening for populations who are at high risk for developing liver cancer. This study was designed to study the levels of a collection of biochemical markers in the sera of patients suffering from hepatocellular carcinoma (HCC) and its predisposing diseases. The ultimate aim is to investigate their diagnostic impact in the early detection of HCC and discriminate from benign liver diseases.

7p kethamoi1 20-11-2019 16 1   Download

To determine whether the soluble programmed cell death ligand 1 (sPD-L1) levels in patients with chronic hepatitis C (CHC) are associated with the clinical features of the disease and the efficacy of treatment, including interferon (IFN)-α.

9p vilusaka2711 19-11-2019 10 1   Download

Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Currently, combined pegylated interferon and ribavirin therapy are the standard treatment. The biological activity of interferon (IFN) is mediated by the induction of intracellular antiviral proteins, such as 20 –50 oligoadenylate synthetase, and dsRNA-activated protein kinase. IFN-inducible doublestranded RNA-activated protein kinase (PKR) is thought to play a key antiviral role against HCV. Some studies observed that PKR expression was higher in sustained viral responders compared with the non-responders.

7p kethamoi1 17-11-2019 13 0   Download

Liver cancer grows silently with mild or no symptoms until advanced. In the absence of an effective treatment for advanced stage of hepatic cancer hope lies in early detection, and screening for high-risk population. Among Egyptians viral hepatitis is the most common risk factor for hepatocellular carcinoma (HCC). The current work was designed to determine the level of prothrombin induced by vitamin K absence-II (PIVKA-II) in sera of patients suffering from HCC and hepatitis C virus (HCV) patients being the most common predisposing factor for HCC.

8p kethamoi1 17-11-2019 9 0   Download