Histone methylation

Lung cancer is one of the most common malignant tumors. Histone methylation was reported to regulate the expression of a variety of genes in cancer. However, comprehensive understanding of the expression profiles of histone methyltransferases and demethylases in lung cancer is still lacking.

9p vinasaki2711 12-11-2019 8 0   Download

Hiệp hội kéo dài trong G2 và M-giai đoạn với nhiễm sắc thể cho phép đủ thời gian cho methyl hóa đầy đủ của tất cả các trang web hemimethylated, đặc biệt là tại nhiều methyl hóa chuỗi tạp sắc (Easwaran et al. 2004). Ngoài ra, Dnmt1 đã được báo cáo để tương tác với histone deacetylases (HDACs) (Fuks et al 2000; Robertson et al 2000; Rountree et al 2000.)

33p kimku12 26-10-2011 61 8   Download

Bất hoạt và methyl hóa retrovirus xảy ra ngay sau khi giới thiệu vào các tế bào phôi (Jahner et al 1982; Stewart et al 1982), nhưng methyl hóa cũng có thể được tiếp theo với một sự kiện im lặng ban đầu phiên mã, vì những thay đổi trong thay đổi histone có thể được phát hiện trước khi methyl hóa gen vừa được giới thiệu

33p kimku12 26-10-2011 40 6   Download

Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease.

310p camchuong_1 04-12-2012 40 4   Download

Tham khảo sách 'methylation - from dna, rna and histones to diseases and treatment by anica dricu', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

310p donghanhmuathi 04-05-2013 40 2   Download

Mixed lineage leukemias (MLLs) are histone-methylating enzymes with critical roles in gene expression, epigenetics and cancer. Although MLLs are important gene regulators little is known about their own regulation. Herein, to understand the effects of toxic stress onMLLgene regulation, we treated human cells with a common food contaminant mycotoxin, deoxynivalenol (DON).

9p viettel02 22-02-2013 21 1   Download

Enhancers cause a high level of transcription and activation of chromatin structure at target genes. Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across target loci by enhancers that function over long distances.

8p vinaphone15 28-02-2013 23 1   Download

KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein complex that requires WDR5.

13p vibaku2711 22-07-2020 4 0   Download

H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression. Our findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. The results reported here provide new molecular insights into the pathogenesis of prostate cancer.

8p vimale2711 21-08-2020 6 0   Download

Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and a decreased level of histone acetylation. Previous studies showed that histone gene reviser and epigenetic changes role significant parts in papillary and anaplastic thyroid cancer tumorigenesis.

11p vimoscow2711 29-08-2020 4 0   Download

Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic changes need further elucidation.

15p vimoscow2711 29-08-2020 2 0   Download

Post-translational modification of histone tails by methylation plays an important role in tumorigenesis. In this study, we investigated the nuclear expression of H3K4me3, H3K9me3 and H4K20me3 in early-stage colon cancer in relation to clinical outcome.

9p vilisa271 22-09-2020 7 0   Download

The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis.

7p viirene2711 03-10-2020 7 0   Download

In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. A large proportion of the cell cycle-regulated histone H3.1 is replaced by H3.3, a histone variant encoded outside the histone repeat cluster and not subject to cell cycle controlled expression.

14p vimariana2711 22-12-2020 3 0   Download

Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may involve the joint chondrocyte degeneration in KOA.

9p vitennessee2711 02-02-2021 0 0   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dynamics of DNA methylation and Histone H4 acetylation during floral bud differentiation in azalea

14p panasonic06 25-12-2011 34 2   Download

CXXC finger protein 1 (Cfp1), encoded by theCXXC1gene, is a compo-nent of the euchromatic Setd1A histone H3K4 methyltransferase complex, and is a critical regulator of histone methylation, cytosine methylation, cel-lular differentiation, and vertebrate development.

13p mobifone23 18-01-2013 36 2   Download

The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and⁄or repressed chromatin states. Thus, histone H3 lysine 4 methylation has a crucial role in maintaining normal cellular functions.

17p mobifone23 21-01-2013 28 2   Download

Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are several pathways, including histone tail mod-ifications, histone variant incorporation, nucleosome remodelling, DNA methylation and noncoding RNAs that together all contribute to the dynamic ‘make-up’ of chromatin under distinct developmental options.

15p inspiron33 25-03-2013 29 2   Download

Folding of DNA into chromatin is mediated by binding to histones such as H4; association of DNA with histones is regulated by covalent histone modifications,e.g. acetylation, methylation,andbiotinylation.We sought to identifyamino-acid residues that are biotinylated in histone H4,and to determine whether acetylation and methylation of histones affect biotinylation. Synthetic peptides spanning fragments of human histone H4 were biotinylated enzymatically using biotinidase. Peptide-bound biotin was probed with strept-avidin–peroxidase....

7p dell39 03-04-2013 28 2   Download