Host factors

Seed-borne rice endophytes are capable of disseminating into host plant tissues as well as to their rhizosphere. Here, we investigated the occurrence of siderophore-producing bacteria (SPB) in the seed endospheres of two distinct rice (Oryza sativa L.) cultivars, TK8 (ssp. japonica) and TCN1 (ssp. indica), and their dissemination into the rhizospheres through culture-dependent methods.

13p vibecca 01-10-2024 2 1   Download

The present study contributed to the body of knowledge by providing a theoretical framework in modelling and predicting host residents’ interactive behaviour towards tourists, and a comprehensive understanding of the roles that psychologic, demographic and socio-graphic factors plays in the different directions of community attitudes towards tourism. It also provided tourism authorities with practical recommendations and implications in terms of tourism planning and a harmonious relationship between the host residents and tourists.

178p runthenight04 02-02-2023 11 5   Download

 Less than 3 decades ago, Robin Warren and Barry Marshall definitively identified Helicobacter pylori by culturing an organism from gastric biopsy specimens that had been visualized for almost a century by pathologists (196). In 1994, H. pylori was recognized as a type I carcinogen, and now it is considered the most common etiologic agent of infection-related cancers, which represent 5.5% of the global cancer burden (239). In 2005, Marshall and Warren were awarded the Nobel Prize of Medicine for their seminal discovery of this bacterium and its role in peptic ulcer disease

27p nguyendangbao1965 04-06-2015 43 4   Download

To establish an infection, Yersinia pseudotuberculosis utilizes a plasmid-encoded type III secretion machine that permits the translocation of several anti-host factors into the cytosol of target eukaryotic cells. Secreted YopD is essential for this process. Pre-secretory stabilization of YopD is mediated by an interaction with its cognate chaperone, LcrH. YopD possesses LcrH binding domains located in the N-terminus and in a predicted amphipathic domain located near the C-terminus. This latter domain is also critical for Yersinia virulence. ...

10p research12 01-06-2013 48 3   Download

Virus infection results in the activation of a set of cellular genes involved in host antiviral defense. IRF-3 has been identifiedas a critical transcription factor in this process. The activationmechanismof IRF-3 is not fully elucidated,yet it involves a conformational change triggered by the virus-dependent phosphorylation of its C-terminus. This con-formational change leads to nuclear accumulation,DNA binding and transcriptional transactivation.

10p tumor12 22-04-2013 38 3   Download

Several microbial pathogens have been reported to interact with glycosaminoglycans (GAGs) on cell surfaces and in the extracellularmatrix. Herewe demonstrate thatM protein, a major surface-expressed virulence factor of the human bac-terial pathogen, Streptococcus pyogenes, mediates binding to various forms of GAGs. Hence, S. pyogenesstrains expressing a large number of different types of M proteins bound to dermatan sulfate (DS), highly sulfated fractions of heparan sulfate (HS) and heparin, whereas strains deficient in M protein surface expression failed to interact with these GAGs. ...

9p fptmusic 16-04-2013 44 6   Download

The leader proteinase (L pro ) of foot-and-mouth disease virus (FMDV) ini-tially cleaves itself from the polyprotein. Subsequently, L pro cleaves the host proteins eukaryotic initiation factor (eIF) 4GI and 4GII. This prevents protein synthesis from capped cellular mRNAs; the viral RNA is still trans-lated, initiating from an internal ribosome entry site. L pro cleaves eIF4GI between residues G674 and R675. We showed previously, however, that L pro binds to residues 640–669 of eIF4GI.

10p awards 06-04-2013 36 4   Download

The bacterial Lsm protein, host factor I (Hfq), is an RNA chaperone involved in many types of RNA transactions such as replication and stabil-ity, control of small RNA activity and polyadenylation. In this latter case, Hfq stimulates poly(A) synthesis and binds poly(A) tails that it protects from exonucleolytic degradation. We show here, that there is a correlation between Hfq binding to the 3¢ end of an RNA molecule and its ability to stimulate RNA elongation catalyzed by poly(A)polymerase I.

0p awards 05-04-2013 27 1   Download

TheHfq (Host factor 1) polypeptide is anucleic acidbinding protein involved in the synthesis of many polypeptides. Hfq particularly affects the translation and the stability of several RNAs. In an earlier study, the use of fold recog-nition methods allowed us to detect a relationship between Escherichia coliHfq and the Sm topology. This topology was further validated by a series of biophysical studies and theHfqstructurewasmodelledonanSmprotein.Hfq forms ab-sheet ring-shaped hexamer.

8p dell39 03-04-2013 53 4   Download

Metallothioneins (MTs) constitute a family of cysteine-rich metalloproteins involved in cytoprotection during pathology. In mammals there are four isoforms (MT-I )IV), of which MT-I and -II (MT-I + II) are the best characterized MT proteins in the brain. Accumulating studies have demon-strated MT-I + II as multipurpose factors important for host defense responses, immunoregulation, cell survival and brain repair.

14p inspiron33 26-03-2013 30 4   Download

Malaria is caused by protozoan parasites of the genusPlasmodiumand is a major cause of mortality and morbidity worldwide. These parasites have a complex life cycle in their mosquito vector and vertebrate hosts. The pri-mary factors contributing to the resurgence of malaria are the appearance of drug-resistant strains of the parasite, the spread of insecticide-resistant strains of the mosquito and the lack of licensed malaria vaccines of proven efficacy.

10p media19 04-03-2013 35 2   Download

Viruses take advantage of cellular machineries to facilitate their gene expression in the host. SR proteins, a superfamily of cellular precursor mRNA splicing factors, contain a domain consisting of repetitive argi-nine⁄serine dipeptides, termed the RS domain.

10p vinaphone15 27-02-2013 35 3   Download

HIV-1 is a retrovirus that causes AIDS in humans. The RNA genome of the virus encodes a Gag polyprotein, which is further processed into matrix, capsid and nucleocapsid proteins. These proteins play a significant role at several steps in the viral life cycle.

10p viettel02 20-02-2013 34 3   Download

In uropathogenic Escherichia coli, UPEC, different types of fimbriae are expressed to mediate interactions with host tissue. FocB belongs to the PapB family of transcription factors involved in the regulation of fimbriae gene clusters. Recent findings suggest that members from this family of proteins may form homomeric or heteromeric complexes and exert both positive and negative effects on the transcription of fimbriae genes.

14p viettel02 19-02-2013 48 4   Download

Tumour necrosis factor-a(TNF-a) is a key mediator of inflammation in host defence against infection and in autoimmune disease. Its production is controlled post-transcriptionally by multiple RNA-binding proteins that interact with the TNF-aAU-rich element and regulate its expression; one of these is Fragile X mental retardation-related protein 1 (FXR1).

12p mobifone23 21-01-2013 40 3   Download

One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation to adverse conditions encountered in the host cells. The ability of Mycobacteriumto successfully adapt to stress condi-tions is brought about by the expression of specific regulons effected by a repertoire of rfactors.

22p mobifone23 18-01-2013 66 5   Download

Anthrax lethal toxin triggers death in some cell types, such as macrophages, and causes a variety of cellular dysfunctions in others. Collectively, these effects dampen the innate and adaptive immune systems to allowBacillus anthracis to survive and proliferate in the mammalian host.

9p mobifone23 18-01-2013 33 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury...

14p thulanh27 13-12-2011 31 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Host factors do not influence the colonization or infection by fluconazole resistant Candida species in hospitalized patients

5p panasonic01 12-12-2011 56 5   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells...

0p thulanh20 12-11-2011 56 2   Download