Infections in kidney transplant recipients

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  • Middle-Period Infections Because of continuing immunosuppression, kidney transplant recipients are predisposed to lung infections characteristic of those in patients with T cell deficiency (i.e., infections with intracellular bacteria, mycobacteria, nocardiae, fungi, viruses, and parasites). The high mortality rates associated with Legionella pneumophila infection (Chap. 141) led to the closing of renal transplant units in hospitals with endemic legionellosis.

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  • Kidney transplant recipients are also subject to infections with other intracellular organisms. These patients may develop pulmonary infections with Nocardia, Aspergillus, and Mucor as well as infections with other pathogens in which the T cell/macrophage axis plays an important role. In patients without IV catheters, L. monocytogenes is a common cause of bacteremia ≥1 month after renal transplantation and should be seriously considered in renal transplant recipients presenting with fever and headache.

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  • Kidney Transplantation (See Table 126-4) Table 126-4 Common Infections after Kidney Transplantation Period after Transplantation Infection Site Early Month) (6 Urinary tract Bacteria (Escherichia Klebsiella, Enterobacteriaceae, Pseudomonas, Enterococcus) associated bacteremia pyelonephritis; Candida coli, (fever, CMV Bacteria (late bone urinary tract marrow suppression, hepatitis); virus with (nephropathy, and graft infections usually not associated BK bacteremia); virus graft with BK (nephropathy, failure, failure, generalized vasculopathy) vasculopathy) Lungs Bacteria ...

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  • (BQ) Part 1 of the document Transplant infections presents the following contents: Introduction to transplant infections, risks and epidemiology of infections after transplantation, specific sites of infection, bacterial infections.

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  • Parvovirus B19 is a single strand DNA virus belongs to the Parvoviridia family and only parvovirus known to be a pathogen in human. It is causing several problems in human especially in immunosuppressed patients such as organ transplant recipients. In kidney transplant patients parvovirus B19 can continue for years due to failure of the immune response and it may be associated with chronic clinical manifestations such as anemia and another reticuloncytopenia. Fifty renal transplant patient who checked up in two main kidney transplant centers in Libya.

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