Lysophosphatidylcholine

Phospholipids are known to influence fibril formation of amyloid beta (Ab) peptide. Here, we show that lysophosphatidylcholine (LPC), a polar phos-pholipid, enhances Ab(1-42) fibril formation, by decreasing the lag time and the critical peptide concentration required for fibril formation, and increasing the fibril elongation rate.

9p mobifone23 07-01-2013 26 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties...

10p thulanh27 13-12-2011 18 2   Download

Lysophosphatidylcholine induces expression of adhesion molecules; how-ever, the underlying molecular mechanisms of this are not well elucidated. In this study, the intracellular signaling by which lysophosphatidylcholine upregulates vascular cell adhesion molecule-1 and P-selectin was delineated using YPEN-1 and HEK293T cells.

12p galaxyss3 21-03-2013 19 2   Download

Mononuclear phagocytes play a pivotal role in the pro-gression of septic shock by producing tumor necrosis factor-a(TNF-a) andother inflammatorymediators in response to lipopolysaccharide (LPS) fromGram-negativebacteria.Our previous studies have shown monocyte and macrophage activationcorrelatewithchanges inmembranephospholipid composition, mediated by acyltransferases. Interferon-c (IFN-c), which activates and primes these cells for enhanced inflammatory responses to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P...

7p fptmusic 16-04-2013 25 1   Download