Measurement system variables

Liver microsomal preparations are routinely used to predict drug interactions that can occurin vivo as a result of inhi-bition of cytochrome P450 (CYP)-mediated metabolism. However, the concentration of free drug (substrate and inhibitor)at its intrahepatic site of action, a variable that cannot be directly measured, may be significantly different from that in microsomal incubation systems.

10p tumor12 20-04-2013 47 4   Download

A WEB-APPLICATION TOOL FOR MANUFACTURING SYSTEMS STRATEGIC MANAG AND COMPETITIVE PERFORMANCE MONITORIN Several identifiable factors may bias the coefficient on the peer group-Tiebout choice interaction in specifications like (7). I discuss two here; each can produce an upward bias in 1 ϕ . The first source of bias is statistical. There are several reasons to suspect measurement error in the peer group variable:

126p mualan_mualan 25-02-2013 55 8   Download