Metabolic machinery

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  • Welcome to the revolutionary weight-loss program designed to jumpstart your metabolism and give you breakthrough weight-loss results. Welcome to a healthy new weight-loss program that emphasizes lowglycemic carbs, an optimal amount of protein and healthy fats, and a mind– body approach to weight loss that will help you lose weight as you never have been able to before. Welcome to a simple-to-follow weight-loss program that’s easy to incorporate into your busy lifestyle and that will be your catalyst to living the life you’ve always dreamed about....

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  • We live in the age of biology—the human and many other organisms’ genomes have been sequenced and we are starting to understand the function of the metabolic machinery responsible for life on our planet. Thousands of new genes have been discovered, many of these coding for enzymes of yet unknown function. Understanding the kinetic behavior of an enzyme provides clues to its possible physiological role. From a biotechnological point of view, knowledge of the catalytic properties of an enzyme is required for the design of immobilized enzyme-based industrial processes.

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  • NA helicases are ubiquitous molecular motor proteins which harness the chemical free energy of ATPhydrolysis to catalyze the unwinding of energetically stable duplex DNA, and thus play important roles in nearly all aspects of nucleic acid metabolism, including replication, repair, recombina-tion, and transcription. They break the hydrogen bonds between the duplex helix and move unidirectionally along the bound strand. All helicases are also translocases and DNA-dependentATPases.Most contain conserved helicase motifs that act as an engine to power DNA unwinding. ...

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  • DNA helicases are molecularmotor enzymes that use the energy of NTP hydrolysis to separate transiently energetic-ally stable duplex DNA into single strands. They are there-fore essential in nearly all DNA metabolic transactions. They act as essential molecular tools for the cellular machinery. Since the discovery of the first DNA helicase in Escherichia coliin1976, several havebeen isolated fromboth prokaryotic and eukaryotic systems.

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  • Misfolded proteins, aggregates, and inclusion bodies are hall-marks of the cytopathology of neurodegenerative disorders including Huntington’s disease, Amyotropic lateral sclerosis, Parkinson’s disease, Prion diseases, and Alzheimer’s disease. The appearance of proteins with altered folded states is regula-ted by the protein folding quality control machinery and age-dependent. We have identified an unexpected molecular link between metabolic state, accumulation of damaged proteins, the heat-shock response and chaperones, and longevity....

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  • Protein synthesis requires both amino acids, as precursors, and a substantial amount of metabolic energy. It is well established that starvation or lack of nutrients impairs pro-tein synthesis in mammalian cells and tissues. Branched chain amino acids are particularly effective in promoting protein synthesis. Recent work has revealed important new information about the mechanisms involved in these effects. Anumber of components of the translational machinery are regulated through signalling events that require the mam-malian target of rapamycin, mTOR. ...

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