Multifunctional

The objective of this project was to develop \(Ti{O_2}\) based multifunctional substrates through silver decoration, while simultaneously enhancing the photocatalytic performance of \(Ti{O_2}\) in the substrate. Employing Ag nanoparticles introduced additional functionality to the system, namely surface-enhanced Raman scattering (SERS), thus enabling the detection of trace amounts of organic molecules prior to their degradation, all with the same substrate.

123p runthenight04 02-02-2023 7 2   Download

The aim of this project was to design, fabricate and characterise multifunctional structural composites incorporating phase change materials for thermal management applications. The specific research objectives to achieve this goal were formulated as follows: Investigate effective methods to integrate microencapsulated PCMs into glass fibrereinforced epoxy composites; Evaluate the mechanical properties of micro-PCMs enhanced FRP composites and investigate associated failure mechanisms; Study the thermal management effectiveness of micro-PCMs enhanced FRP composites.

125p runthenight04 02-02-2023 11 3   Download

The objectives of the thesis: Manufacturing multifunctional nanoparticles including: Fe3O4 nanoparticles (magnetical properties) coated with biocompatible polymers, attaching drugs (Cur, Dox) and targeted folate factor (optical properties)) that are well dispersed in water, able to target the cancer.Experiment and evaluate the effect of the nanoparticles on cancer cell lines such as HT29; HeLa; HepG2 ... and on experimental animals.

27p xacxuoc4321 09-07-2019 62 5   Download

Kininogens are multifunctional proteins found so far mainly in mammals. They carry vasoactive kinins as well as participate in defense, blood coagulation and the acute phase response. In this study, novel kininogens were isolated from Atlantic cod (Gadus morhua L.) and spotted wolffish (Anarhichas minor) by papain-affinity chromatography. The molecular mass of cod kininogen determined by MALDITOF mass spectrometry to be 51.0 kDa and it had pI values of 3.6, 3.9 and 4.4.

8p system191 01-06-2013 38 5   Download

Two genes (CM-AAT1 and CM-AAT2) with strong sequence homology (87% identity at the protein level) putatively involved in the formation of aroma volatile esters have been isolated from Charentais melon fruit. They belong to a large and highly divergent family of multifunctional plant acyl-transferases and show at most 21% identity to the only other fruit acyl-transferase characterized so far in strawberry. RT-PCR studies indicated that both genes were specifically expressed in fruit at increasing rates in the early and mid phases of ripening.

8p research12 01-06-2013 49 4   Download

Hyaluronan-binding protein 1 (HABP1), a ubiquitous multifunctional protein, interacts with hyaluronan, globular head of complement component 1q (gC1q), and clustered mannose and has been shown to be involved in cell sig-nalling.In vitro, this recombinant protein isolated from human ®broblast exists in di€erent oligomeric forms, as is evident from the results of various independent techniques in near-physiological conditions.

9p research12 29-04-2013 29 4   Download

Zinc (Zn), an endogenous regulator of apoptosis, and has abilitiesboth to induceapoptosis and inhibit the inductionof apoptosis via the modulation of caspase activity. Due to the multifunctions of Zn, the intracellular Zn level is strictly regulated by a complex system in physiological and patho-logical conditions. The commitment of Zn to the regulation of apoptosis is not fully understood. In the present study, we investigated the role of intracellular Zn level in the induction of apoptosis in human leukemia cells (HL-60 cells) using a Zn ionophore [pyrithione (Py)]....

8p tumor12 22-04-2013 28 2   Download

GlutathioneS-transferases (EC 2.5.1.18) (GSTs), are a family of multifunctional enzymes present in all living organisms whose main function is the detoxification of electrophilic compounds. GSTs are considered the most prominent detoxifying class II enzymes in helminths. We describehere the characterizationof novel dehydroascorbate reductase and thiol transferase activities that reside in the human parasite Schistosoma mansoni GSTx.

10p tumor12 22-04-2013 32 2   Download

Gelsolin is a multidomain and multifunction protein that nucleates the assembly of filaments and severs them. The activation of gelsolin by calcium is a multistep process involving many calcium binding sites that act to unfold the molecule from a tight structure to a more loose form in which three actin-binding sites become exposed. Low pHis alsoknowntoactivategelsolin, in theabsenceof calciumand this too results in an unfolding of the molecule.

8p tumor12 20-04-2013 42 3   Download

RNA helicase II⁄Guais a multifunctional nucleolar protein involved in ribosomal RNA processing inXenopus laevisoocytes and mammalian cells. Downregulation of Guausing small interfering RNA (siRNA) in HeLa cells resulted in 80% inhibition of both 18S and 28S rRNA production. The mechanisms underlying this effect remain unclear. Here we show that in mammalian cells, Guaphysically interacts with ribosomal protein L4 (RPL4), a component of 60S ribosome large subunit.

15p fptmusic 11-04-2013 36 2   Download

Interleukin (IL)-11 is a multifunctional cytokine that stimulates hematopoi-etic progenitor cells and exerts a series of important immunomodulatory effects. It was believed to be restricted to mammals, but here we report the first nonmammalianIL-11 gene, in rainbow trout (Oncorhynchus mykiss). A trout IL-11 cDNA clone was isolated that contains a 5¢-untranslated region (UTR) of 400 bp, an open reading frame of 612 bp and a large 3¢-UTR of 1924 bp.

12p awards 05-04-2013 30 4   Download

Human kynurenine aminotransferase I/glutamine trans-aminase K (hKAT-I) is an important multifunctional enzyme. This study systematically studies the substrates of hKAT-I and reassesses the effects of pH, Tris, amino acids anda-keto acids on the activity of the enzyme. The experi-ments were comprised of functional expression of the hKAT-I in an insect cell/baculovirus expression system, purification of its recombinant protein, and functional characterization of the purified enzyme.

11p awards 05-04-2013 40 4   Download

The properties of theD6 desaturase/acetylenase from the mossCeratodon purpureusand theD12 acetylenase from the dicotCrepis alpinawere studied by expressing the encoding genes inArabidopsis thalianaandSaccharomyces cerevisiae. The acetylenase fromC. alpinaD12 desaturated both oleate and linoleate with about equal efficiency. The desaturation of oleate gave rise to 9(Z),12(E)- and 9(Z),12(Z)-octadeca-dienoates in a ratio of approximately 3 : 1.

0p awards 05-04-2013 41 3   Download

Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer. Indeed, Lf has been reported to inhibit the proliferation of cancerous mammary gland epi-thelial cells and manifest a potent antiviral activity against human immunodeficiency virus and human cytomegalo-virus. The Lf-binding sites on the cell surface appear to be proteoglycans and other as yet undefined protein(s).

15p dell39 03-04-2013 46 5   Download

A cDNA encoding a novel plant type III polyketide synthase was cloned and sequenced from the Chinese club moss Huperzia serrata(Huperzia-ceae). The deduced amino acid sequence ofHu. serratapolyketide synthase 1 showed 44–66% identity to those of other chalcone synthase superfamily enzymes of plant origin.

10p galaxyss3 21-03-2013 39 4   Download

Hepatocyte growth factor activator (HGFA) is a serine protease and a potent activator of prohepatocyte growth factor⁄scatter factor (pro-HGF⁄SF), a multifunctional growth factor that is critically involved in tis-sue morphogenesis, regeneration, and tumor progression.

15p media19 06-03-2013 30 3   Download

The potent immunomodulatory, anti-inflammatory and procoagulant properties of protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have previously been found to be modulated by a supramolecular monomer–trimer equilibrium.

12p media19 05-03-2013 39 3   Download

Decorin is a multifunctional small leucine-rich proteoglycan involved in the regulation of collagen fibrillogenesis. In patients with a variant of Ehlers– Danlos syndrome, about half of the secreted decorin lacks the single gly-cosaminoglycan side chain.

10p media19 04-03-2013 49 2   Download

EspB is a multifunctional protein associated with the type III secretion system of enterohaemorrhagic Escherichia coli, and interacts with various biomolecules includinga-catenin in the host cell. The binding of EspB to a-catenin is thought be involved in actin reorganization during bacterial infection, although the precise mechanism of this phenomenon is still unclear.

8p vinaphone15 28-02-2013 29 4   Download

Lipocalin-type prostaglandin D synthase (L-PGDS) is a multifunctional protein that produces prostaglandin D2 and binds and transports various lipophilic substances after secretion into various body fluids as b-trace. L-PGDS has been proposed to be a useful diagnostic marker for renal injury associated with diabetes or hypertension, because the urinary and plasma concentrations are increased in patients with these diseases.

13p vinaphone15 25-02-2013 49 4   Download