Multistability

Pig kidney fructose-1,6-bisphosphatase is a homotetrameric enzyme which does not contain tryptophan. In a previous report the guanidine hydrochlo-ride-induced unfolding of the enzyme has been described as a multistate process [Reyes, A. M., Ludwig, H. C., Yan˜ez, A. J., Rodriguez, P. H and Slebe, J. C.

13p media19 04-03-2013 31 2   Download

Poly(A)-specific ribonuclease (PARN) specifically catalyzes the degradation of the poly(A) tails of single-stranded mRNAs in a highly processive mode. PARN participates in diverse and important intracellular processes by act-ing as a regulator of mRNA stability and translational efficiency. In this article, the equilibrium unfolding of PARN was studied using both guani-dine hydrochloride and urea as chemical denaturants.

12p viettel02 22-02-2013 41 4   Download