Oral role plays

AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I inhibitor irinotecan is used clinically to treat colorectal cancer (CRC), often in combination with 5-fluorouracil (5FU).

13p vialfrednobel 23-12-2023 6 3   Download

Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood. Methods We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.

19p vischultz 20-10-2023 4 1   Download

Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcinoma (OSCC). However, a lack of comprehensive molecular biological analysis leaves the regulatory mechanisms of CAFsExo in OSCC unclear.

14p visharma 20-10-2023 2 2   Download

Background and Objectives: Choosing the appropriate drug has been playing an important role in the treatment in hospitals. The survey of the process of selecting and developing a list of drugs aims to point out inadequacies, thereby taking timely solutions to increase the rational use of drugs. The objective of the study was to survey the process of selecting and developing a drug formulary of Da Nang Psychiatric Hospital (DNPH).

7p nhanchienthien 25-07-2023 3 2   Download

Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual’s susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder cancer and cervical cancer.

9p vinarcissa 21-03-2023 3 1   Download

Functional genetic variation plays an important role in predicting patients’ response to chemotherapeutic agents. A growing catalogue of mitochondrial DNA (mtDNA) alterations in various cancers point to their important roles in altering the drug responsiveness and survival of cancer cells.

4p vihagrid 30-01-2023 6 3   Download

Dental caries is a common disease and is acquired very early in children after teething. Primitive teeth play an important role in chewing, so oral disease will affect the physical development of children. The objective of the study was to investigate the current status of oral disease, the role of the mother and related factors of 3-5 year-old children.

7p viangelamerkel 18-07-2022 10 5   Download

Oral health is essential for daily living and plays a pivotal role in overall health conditions and wellbeing. This study evaluated the impact of self-reported oral health on geriatric conditions, institutionalization, and mortality.

8p vinobelprisen 26-03-2022 12 4   Download

The epidermal growth factor receptors participate in the physiological processes such as regulation of morphogenesis, proliferation and cell migration, but when overexpressed or overactivated they may play an important role in neoplastic progression.

11p vigalileogalilei 28-02-2022 9 1   Download

Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer.

8p vijennie2711 25-09-2020 30 0   Download

Epigenetic modifications play important roles in the regulation of gene expression determining cellular phenotype as well as various pathologies such as cancer. Although the loss of keratin 13 (KRT13) is reportedly linked to malignant transformation of oral epithelial cells, the molecular mechanisms through which KRT13 is repressed in oral squamous cell carcinoma (OSCC) remain unclear.

8p vialabama2711 21-09-2020 9 1   Download

The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invasion.

9p vidhaka2711 31-07-2020 13 1   Download

Inflammasomes are reported to be abnormally expressed and activated in several malignancies and play important roles in tumor development. The present study was designed to investigate the expression and function of the NLR family pyrin domain containing protein 3 (NLRP3) inflammasome in oral squamous cell carcinoma (OSCC).

10p vibaku2711 22-07-2020 11 1   Download

Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor development. However, the mechanism of circRNA action in human OSCC remains largely unknown.

13p vikuala271 13-06-2020 5 0   Download

The NTRK2 genetic locus encodes neurotrophin membrane receptors that play an important role in normal neural tissue plasticity, growth, and survival. One NTRK2-encoded protein is TrkB-FL, which can regulate multiple pathways relevant to cancer.

12p vikuala271 13-06-2020 15 0   Download

Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma (OSCC) remain unclear.

10p vikuala271 13-06-2020 9 1   Download

Communication strategies (CSs) play a significant role in enabling EFL students to achieve a higher level of English proficiency and good ability in oral communication. Helping both EFL teachers and students gain awareness of CSs is essential in the Vietnamese context. This study, therefore, aimed to explore the most commonly used strategies in English oral communication among English-majored students at Ho Chi Minh City University of Technology (HUTECH), Vietnam.

24p partimesinhvien 08-05-2020 56 2   Download

Recent researches have been focusing on mucosal immune adjuvants, which play the key roles in mucosal immunization and have become the limitation for non-injected vaccine development.

6p vihamax2711 21-04-2020 15 0   Download

Lactobacillus spp. play a major role in the development of dental caries. Although effective methods are known for the prevention and management of dental caries, its prevalence of dental caries is increasing amongst school-age children in Ethiopia.

9p vivalanbo2711 19-03-2020 6 0   Download

Human saliva plays a pivotal role in digesting food and maintaining oral hygiene. The presence of electrolytes, mucus, glycoproteins, enzymes, antibacterial compounds, and gingival crevicular fluid in saliva ensures the optimum condition of oral cavity and general health condition. Saliva collection has been proven non-invasive, convenient, and inexpensive compared to conventional venipuncture procedure.

7p viwashington2711 04-12-2019 6 1   Download