Pharmacological strategies

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  • Three distinct sequential cellular responses characterise the reaction of the adult spinal cord and brain to injury. An acute haemorrhagic phase immediately ensues after wounding, in which haematogenous cells flood the lesion site. This is followed by a subacute period during which macrophages clear necrotic debris, glial cell reactions are mobilised, the clot becomes organised, and scarring is initiated. Finally, the scar tissue contracts during a consolidation phase .

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  • Cet ouvrage présente les travaux du groupe de travail réuni par l’Inserm et l’Institut de veille sanitaire (InVS) dans le cadre de la procédure d’expertise opérationnelle pour répondre à la demande de la Direction générale de la santé concernant les stratégies de dépistage du saturnisme chez l’enfant. Il constitue un prolongement et un complément de l’expertise collective publiée en 1999 intitulée « Plomb dans l’environnement : quels risques pour la santé ? ».

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  • Emergency Vascular Surgery – A Practical Guide provides a concise guide to managing patients with all kinds of emergent vascular problems. It is not intended to be a “classic” textbook, so the background information given is very concise. The focus is instead on management and treatment, especially open surgical strategies. The text is written for newcomers to the vascular surgical field, for surgical trainees, and for all doctors who treat emergent vascular surgical patients in the emergency department....

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  • Times have changed and so should our intellectual basis for the management of diseases and conditions. Once thought of as an anatomic structure containing disparate and unrelated viscera, the human pelvis is now appreciated as a functional syncytium as complex as any within the human body. The dysfunctions of urinary, genital, and gastrointestinal elements which constitute this complex functional–anatomic arrangement require comprehensive and inclusive management strategies.

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  • Despite the significant decline in heart disease mortaht' rates over the last 25 years, heart failure has remained a significant problem. We are now confronted with large numbers of terminally ill patients for whom conventional therapies for heart failure have been exhausted and for whom repeated hospital visits are necessary. There now is a major thrust towards a management strategy which embraces a comprehensive approach including vigorous preventive measures and earlier surgical interventions.

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  • Since this book was first published in 1993, the Advanced Paediatric Life Support (APLS) concept and courses have gone a great way towards their aim of bringing simple guidelines for the management of ill and injured children to front-line doctors and nurses. Over the years an increasing number of experts have contributed to the work and we extend our thanks both to them and also to our instructors who unceasingly provide helpful feedback.The Advanced Paediatric Life Support Course is now well established in several countries outside the United Kingdom.

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  • Increasing numbers of children are recognised as experiencing an autistic spectrum disorder, and educational provision for most of these children is found within a mainstream school. Autistic spectrum disorders (ASDs) are also sometimes referred to as pervasive development disorders because they pervade so many areas of life and are intrinsic to that individual’s development.

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  • In this chapter I will review the current status of treatment for schizophrenia in terms of effectiveness and safety, and discuss what treatment advances have been made in the last century, and how treatment interventions might and should develop as the 21st century unfolds.

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  • The molecular biology and mechanical properties of tendon and ligament healing and soft tissue (i.e., tendon, ligament, capsular tissues) to bone are a vital aspect of many surgical disciplines. Recent advances, both surgical and experimental, have provided great insight into new techniques, mechanisms of healing, and strategies for augmentation and repair.

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  • Our goal in this book is to provide the reader with only the most crucial and important points for the variety of disorders likely to be encountered in the adult intensive care unit, including the key first steps in diagnosis, confirmation of diagnosis, and initial management strategies. In preparing the manuscript, we were struck by several insights. First was the importance of general supportive care of the patient regardless of the primary diagnosis leading to admission to the ICU.

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  • Healthcare in the UK has experienced intense change over the past few years, much of which has been focused on the perioperative environment. The NHS Plan, introduced by the Labour government in 2000, was at the forefront of the modernisation of the UK’s National Health Service. Focusing on major areas of concern, such as modernisation of the workforce, increasing patient choice, and increasing the efficiency and effectiveness of patient care, the government strategy to rebuild the NHS has affected every segment of the care sector....

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  • This volume is based on the proceedings of the first annual Peacocks polycystic ovary syndrome (PCOS) Forum on Disease Mechanisms and Therapeutic Strategies, October 6–9, 2005, Chateau de Vault de Lugny, Avallon, France. The Peacocks was founded by R. Jeffrey Chang, Andrea Dunaif, Stephen Franks, Richard S. Legro, and Samuel S. C. Yen. The name is based on PCOS when it is pronounced as a word “pcos” rather than as individual letters. The purpose of the Peacocks is to organize biannual meetings of experts to review the latest developments in the field.

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  • Equally bewildering to the student are the proper use of diagnostic tests and the integration of the results into the clinical assessment. The novice medical practitioner typically uses a "shotgun" approach to testing, hoping to hit a target without knowing exactly what that target is. The expert, on the other hand, usually has a specific target in mind and efficiently adjusts the testing strategy to it. The second goal of this chapter is to review briefly some of the crucial basic statistical concepts that govern the proper interpretation and use of diagnostic tests.

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  • The origins of tissue engineering date to the sixteenth century when complex skin flaps were used to replace the nose. Modern tissue engineering combines the disciplines of materials sciences and life sciences to replace a diseased or damaged organ with a living, functional substitute. The most common tissue engineering approach combines cells and matrices to produce a living structure (Fig. 69-1). These strategies also include the use of scaffolding, cells, and growth factors to shape new tissues.

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  • Urinary incontinence and pelvic prolapse have affected the quality of many lives over the years. Only recently, however, has increased attention to these areas led to a better understanding of the epidemiology, pathophysiology, and newer approaches to treatment, both from the pharmacological and device standpoint. This text is a step forward in bringing these new innovations together in a comprehensive and well-organized manner.

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  • The Thematic Strategy was published in late 2005 and constitutes an important step in a series of initiatives that have contributed to the development of Europe’s policy on the urban environment. Given the diversity of urban areas and existing national, regional and local circumstances the Strategy does not dictate the solutions that cities should adopt as it would be impossible to propose a "one size fits all" approach.

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  • With publication of the human genome has come an experiment in reductionism for drug discovery. With the evaluation of the number and quality of new drug treatments from this approach has come a reevaluation of target-based versus systems-based strategies. Pharmacology, historically rooted in systems-based approaches and designed to give systems-independent measures of drug activity, is suitably poised to be a major (if not the major) tool in this new environment of drug discovery.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Recent developments and strategies in pediatric pharmacology research in the USA...

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  • We briefly introduce the most common lysosomal storage disorder, Gau-cher disease, concisely describe the Food and Drug Administration approved strategies to ameliorate Gaucher disease, and then outline the emerging pharmacologic chaperone strategy that offers the promise to remedy this malady.

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  • PARKSERVICE is a new telemedical application combining home-based support for people with Parkinson’s disease (PD) and a PD-specific walking aid which uses a strategy known as visual cueing. PD is estimated to affect 100-180 per 100,000 of the population (with most surveys favoring the higher estimate) and has an annual incidence of 4-20 per 100,000[1],[2]. Taking a population of approximately 450M citizens this implies 450,000-900,000 people with PD (PWP) in the EU.

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