Pharmacology

The aim of this study was to investigate the potential impact of obesity on patients’ clinical outcome and response to the usual post orthopaedic surgery thromboprophylaxis enoxaparin or aspirin. Additionally, the participants perceived barrier(s) to adherence to the prescribed prophylaxis were explored.

224p runthenight04 02-02-2023 2 1   Download

The aims of this study are to (1) review the fundamental knowledge of AR from the perspectives of the Western medicine and CM perspectives, (2) investigate the effectiveness and the safety of CHM used for the management of AR by conducting a systematic review (SR) of the RCTs, (3) elucidate the pharmacological effects and the mechanisms of actions of the five herbs commonly used in the RCTs, and (4) extract the herbs used in retrospective diagnosis of ARlike signs and symptoms from the classical texts, conduct pattern analyses of the herbs used classically by employing principal component a...

255p runthenight04 02-02-2023 7 3   Download

Đề tài "Nghiên cứu tác dụng chống lão hoá của Lãnh công (Fissistigma oldhamii (Hemsl.) Merr.) trên một số enzyme kết hợp mô hình dược lý mạng in silico" nghiên cứu nhằm đánh giá tác dụng sinh học của Lãnh công qua mô hình thu dọn gốc tự do DPPH và khả năng ức chế các enzyme Tyrosinase, Elastase và Hyaluronidase; phân tích, dự đoán cơ chế chống lão hóa của Lãnh công sử dụng phương pháp network pharmacology.

54p unforgottennight09 26-10-2022 22 9   Download

Đề tài "Nghiên cứu xây dựng quy trình định lượng Mangiferin trong cây Tri mẫu bằng phương pháp HPLC" nghiên cứu xác định thành phần hoạt chất quan trọng của Tri mẫu trong điều trị biến chứng trên thần kinh trung ương do bệnh đái tháo đường bằng phương pháp network pharmacology; xây dựng và thẩm định quy trình định lượng Mangiferin (thành phần hoạt chất quan trọng của Tri mẫu trong điều trị DN, thu được từ mục tiêu 1) trong cây Tri mẫu bằng phương pháp HPLC.

72p unforgottennight09 26-10-2022 38 11   Download

In diabetic patients, the body does not produce enough insulin or not properly respond to insulin. Insulin is a hormone produced by -cells of the pancreas. It stimulates the cells to absorb the glucose from the blood and its hyposecretion may leads to the over accumulation of glucose in the blood and often leading to various complications.

82p spiritedaway36 26-11-2021 18 2   Download

The objectives of the thesis: Determine the chemical composition of three soft coral species S. nanolobata, S. conferta, S. leptoclados collected in the central sea of Vietnam; đetecting active substances with cytotoxic activity in soft corals studied, orienting their application for biomedical and pharmacological studies.

26p closefriend09 16-11-2021 15 4   Download

Achieve the following objectives: 1. Evaluate the occupational activities and identify of some factors affecting professional activities of managers in pharmacies and drugstores reaching GPP standard in Dong Nai province from November 2012 -September 2014.

30p petsematary 02-06-2021 8 2   Download

Research objectives of the thesis: Determining suitable conditions for squalene extraction and purification from selectable S. mangrovei PQ6 strain; evaluating the safety and pharmacological/biological effects of extracted squalene oriented as feed stock for human health food, cosmetics and pharmaceuticals.

27p extraenglish 24-05-2021 22 4   Download

Determining suitable conditions for squalene extraction and purification from selectable S. mangrovei PQ6 strain; evaluating the safety and pharmacological/biological effects of extracted squalene oriented as feed stock for human health food, cosmetics and pharmaceuticals.

27p capheviahe27 23-02-2021 27 4   Download

The silver and gold nanoparticles were biosynthesized using leaves of a pharmacologically important plant Heliconia rostrata.

8p tocectocec 25-05-2020 8 1   Download

Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient.

15p tramnamcodon_01 28-03-2016 68 2   Download

The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determination regarding their application to be made by the physician in light of each patient’s individual circumstances. Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome.

16p tramnamcodon_01 28-03-2016 62 1   Download

Oxford Centre for Molecular Sciences and the Dyson Perrins Laboratory, Oxford, UK; 2Department of Biochemistry, National Defence Medical Centre, Taipei, Taiwan; 3Department of Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicillin N, the committed step in the biosynthesis of cephamycin C by Streptomyces clavuligerus.

5p system191 01-06-2013 24 3   Download

A potential ancestral gene Erik Salaneck1, Robert Fredriksson1, Earl T. Larson1, J. Michael Conlon2 and Dan Larhammar1 Unit of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden; 2Regulatory Peptide Center, Creighton University School of Medicine, Omaha, Nebraska, USA We report here the isolation and functional expression of a neuropeptide Y (NPY) receptor from the river lamprey, Lampetra fluviatilis. The receptor displays

9p system191 01-06-2013 29 3   Download

Pi4 is a38-residue toxincross-linkedby fourdisulfidebridges that has been isolated from the venom of the Chactidae scorpion Pandinus imperator. Together with maurotoxin, Pi1, Pi7 andHsTx1, Pi4belongs to theaKTX6 subfamilyof short four-disulfide-bridged scorpion toxins acting on K + channels. Due to its very low abundance in venom, Pi4 was chemically synthesized in order to better characterize its pharmacology and structural properties.

10p tumor12 20-04-2013 31 1   Download

We report the cloning, expression, pharmacological char-acterization and tissue distribution of a melanocortin (MC) receptor gene in a shark, the spiny dogfish (Squalus acanth-ias) (Sac). Phylogenetic analysis showed that this receptor is anorthologof theMC4 subtype, sharing71%overall amino acid identity with the human (Hsa) MC4 receptor. When expressedandcharacterizedbyradioligandbindingassay for the natural MSH (melanocyte-stimulating hormone) pep-tides a-, b-, and c-MSH, the SacMC4 receptor showed pharmacological properties very similar to the HsaMC4 receptor. ...

9p tumor12 20-04-2013 49 3   Download

Scorpion toxins that affect sodium channel (NaCh) gating in excitable cells are divided into a-andb-classes. Whereas a-toxinshavebeen found inscorpions throughout theworld, anti-mammalianb-toxins have been assigned, thus far, to
New World scorpions while anti-insect selective b-toxins (depressant and excitatory) have been described only in the
Old World. 2 This distribution suggested that diversification ofb-toxins into distinct pharmacological groups occurred after the separation of the continents, 150 million years ago....

8p fptmusic 16-04-2013 27 2   Download

Many pharmacologically important agents are assembled on multimodular nonribosomal peptide synthetases (NRPSs) whose modules comprise a set of core domains with all essential catalytic functions necessary for the incorporation and modification of one building block. Very often, d-amino acids are found in such products which, with few exceptions, are generated by the action of NRPS integrated epimerization (E) domains that alter the stereochemistry of the corresponding peptidyl carrier protein (PCP) bound l-intermediate....

15p fptmusic 12-04-2013 30 2   Download

A wide range of approaches has been applied to examine the quaternary structure of G protein-coupled receptors, the basis of such protein–protein interactions and how such interactions might modulate the pharmacology and function of these receptors. These include coimmunoprecipitation, var-ious adaptations of resonance energy transfer techniques, functional com-plementation studies and the analysis of ligand-binding data.

12p fptmusic 11-04-2013 50 3   Download

Although highly controversial just a few years ago, the idea that G-pro-tein-coupled receptors (GPCRs) may undergo homo-oligomerization or hetero-oligomerization has recently gained considerable attention. The recognition that GPCRs may exhibit either dimeric or oligomeric structures is based on a number of different biochemical and biophysical approaches.

8p fptmusic 11-04-2013 51 2   Download