Plasma antioxidant

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  • Free radicals are constantly formed in living cells and removed by antioxidant defenses. Antioxidant enzymes are the main line of defense against free radicals in animal and plant cells. Uncontrolled generation ROS are involved in a number of human disease states, including diabetes and cancer due to disturbance in cellular and molecular processes including cell growth, differentiation and proliferation.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Plasma redox status is impaired in the portacaval shunted rat – the risk of the reduced antioxidant ability...

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  • Antioxidant protein 2 (AOP2) is a member of a family of thiol-specific antioxidants, recently renamedperoxiredoxins, that evolvedas part of anelaborate systemtocounteract and control detrimental effects of oxygen radicals. AOP2 is found in endothelial cells, erythrocytes, monocytes, T andB cells, but not in granulocytes. AOP2 was found solely in the cytoplasm and was not associated with the nuclear or membrane fractions; neither was it detectable in plasma.

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  • everal advantageous effects of vitamin C on human health have been stressed, such as the relationship between high plasma vitamin C concentration and reduced gastric cancer risk found in EPIC study (Jenab et al., 2006). Besides the antioxidant activity of vitamin C, which may explain its protective role against gastric cancer risk, several other activities could play a role, such as its ability to modulate cell growth kinetics and its putative antimicrobial activity, for example against Helicobacter pylori, a bacteria responsible for chronic ulcer and even stomach cancer.

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  • Bioaccessible unabsorbed polyphenols may play a role in the protection of the GI tract against RONS prior to their fecal excretion. In contrast to native polyphenols, less data exists on the antioxidant activity of bioavailable polyphenol phase II metabolites (conjugated derivatives).

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  • We reported earlier that urate may behave as a pro-oxidant in Cu 2+ -induced oxidation of diluted plasma. Thus,its effect on Cu 2+ -induced oxidation of isolated low-density lipoprotein (LDL) was investigated by mon-itoring the formation of malondialdehyde and conjugated dienes and the consumption of urate and carotenoids. We show that urate is antioxidant at high concentration but pro-oxidant at low concentration.

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