Pore and interconnection

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  • Porogen leaching is one of the most common methods used for preparation of scaffolds with controlled porosity. The particulate leaching method is totally based upon the dispersion of porogen (salt, sugar and wax) either in liquid particulates or powdered materials (Hou et al., 2003; Lee et al., 2004, Nazarov et al., 2004 Vepari & Kaplan, 2007) by the process of evaporation, cross linking or other reaction liquid may be solidified. These porogens act as place holder for pore and interconnection of the pores in the actual scaffolds fabrication technique.

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  • With the rapid development of nanoscience and nanotechnology over the last decades, great progress has been made not only in the preparation and characterization of nanomaterials, but also in their functional applications. As an important one- dimensional nanomaterial, nanofibers have extremely high specific surface area because of their small diameters, and nanofiber membranes are highly porous with excellent pore interconnectivity.

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  • A combination of gel-casting and polymeric foam infiltration methods is used in this study to prepare porous bodies of hydroxyapatite (HA), to provide a better control over the microstructures of samples. These scaffolds were prepared by impregnating a body of porous polyurethane foam with slurry containing HA powder, and using a percentage of solids between 40% and 50% w/v, and three different types of monomers to provide a better performance.

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  • The osteogenic capability of the scaffold is influenced by the interconnections between the scaffold pores which facilitate cell distribution, integration with the host tissue and capillary ingrowth. Hence, the preparation of bone scaffolds with applicable pore size and interconnectivity is a significant issue in bone tissue engineering

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  • Thermal cycling tests showed that the adhesion of the TiC, ZrC, and ZrO2 coating layers with niobium was relatively weak compared to the TaC and Y2O3 coatings. The TaC and Y2O3 coatings had better cycling characteristics with no interconnected cracks. In the interaction studies, ZrC and ZrO2 coated rods showed significant degradations after exposure to U-10 wt.% Zr melt at 1600ºC for 15 min., but TaC, TiC, and Y2O3 coatings showed good compatibility with U-Zr melt.

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