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Preclinical and clinical stages

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  • Biomarkers are the keystone of stratified medicine. Now, as for any new medical product, the development of bioassays follows a pathway that begins with basic research and moves toward preclinical and clinical stages. Although biomarkers can be identified in clinical phases, the discovery of new biomarkers is often ground in knowledge generated by academic basic research. A better understanding of disease mechanisms is crucial in this respect.

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  • Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...

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  • Previous studies have demonstrated the utility and sensitivity of the CogState Brief Battery (CBB) in detecting cognitive impairment in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and in assessing cognitive changes in the preclinical stages of AD. Thus, the CBB may be a useful screening tool to assist in the management of cognitive function in clinical settings.

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