Progression and therapy

It is becoming increasingly clear that signals generated in tumor microenvi-ronments are crucial to tumor cell behavior, such as survival, progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites and to localize to distant organs.

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of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Paulistrasse 10, CH-8093 Zurich, Switzerland 2Institute of Pathology, Helios Klinikum Erfurt, Nordhaeuser Strasse 74, D-99089 Erfurt, Germany Corresponding author: Dario Neri, neri@pharma.ethz.ch Received: 12 Oct 2006 Revisions requested: 6 Dec 2006 Revisions received: 12 Jan 2007 Accepted: 29 Jan 2007 Published: 29 Jan 2007 Arthritis Research & Therapy 2007, 9:R9 (doi:10.1186/ar2115) This article is online at: http://arthritis-research.com/content/9/1/R9 © 2007 Trachsel et al.

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