Prostaglandins

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults exhibiting infiltration into surrounding tissues, recurrence, and resistance to therapy. GBM infiltration is accomplished by many deregulated factors such as cell adhesion molecules (CAMs), which are membrane proteins that participate in cell-cell and cell-ECM interactions to regulate survival, proliferation, migration, and stemness.

12p visusanwojcicki 28-06-2022 3 1   Download

Bài giảng Khởi phát chuyển dạ: Cập nhật phương pháp sử dụng Prostaglandin E2 tại Bệnh viện Phụ sản Hải Phòng do PGS.TS.BS Vũ Văn Tâm trình bày đánh giá kết quả sử dụng Prostaglandin E2 tại Bệnh viện Phụ sản Hải Phòng từ 10/2018 đến 3/2019.

25p viabigailjohnson 10-06-2022 12 2   Download

Previous studies showed that cyclooxygenase(COX) was involved in ischemia/reperfusion (I/R) injuries. Parecoxib, a selective inhibitor for COX −2, has been shown to have protective properties in reducing I/R injury in the heart, kidney and brain.

8p viisaacnewton 25-04-2022 4 1   Download

Hoán vị đại động mạch (HVĐĐM) là tật tim bẩm sinh nặng, thường gặp. Trẻ thường có dự hậu tốt nếu được điều trị thích hợp. Tuy nhiên, trên thực tế, còn nhiều khó khăn, cả về thời điểm điều trị tạm thời và phẫu thuật trong việc điều trị tật tim này. Bài viết trình bày xác định đặc điểm điều trị tạm thời tật hoán vị đại động mạch ở trẻ sơ sinh tại bệnh viện Nhi Đồng 2.

6p viedison 13-04-2022 21 1   Download

Cổ tử cung không thuận lợi là một thách thức trong khởi phát chuyển dạ với mục tiêu sinh đường âm đạo. Trong đó, Prostaglandin, đặc biệt là Prostaglandin E2 , đóng vai trò quan trọng trong quá trình phân giải, phá vỡ cấu trúc collagen dẫn đến chín muồi cổ tử cung. Các phương pháp cơ học làm chín muồi cổ tử cung bằng cơ chế tăng áp lực trực tiếp lên cấu trúc cổ tử cung và màng ối. Qua đó giải phóng các Prostaglandin từ màng rụng và cổ tử cung.

7p vilouispasteur 10-03-2022 26 2   Download

Equine endometrosis is a chronic degenerative condition, described as endometrial fibrosis that forms in the stroma, under the basement membrane and around the endometrial glands. The role of lysophosphatidic acid (LPA) in the development of tissue fibrosis varies depending on the organ, and its profibrotic role in mare endometrosis remains unclear.

13p vigandhi 23-02-2022 22 1   Download

Chronic inflammation mediated by the cyclooxygenase enzymes, specifically their product prostaglandin E2 (PGE2), can result in the development of cancer. PGE2 promotes cell proliferation, apoptosis, and angiogenesis through interaction with its specific receptors (EP1 receptor - EP4 receptor [EP1R-EP4R]).

10p vigandhi 23-02-2022 10 1   Download

Extracellular vesicles (EVs) are a promising biomarker and play a vital role in cell–cell communication. This study aimed (I) to identify and characterize EVs from low volume uterine lavage (LVL) and serum in mares with endometritis, compared to healthy controls and (II) to measure serum levels of interleukin 6 (IL-6), and prostaglandins (PGF2α and PGE2).

12p vidarwin 22-02-2022 3 1   Download

Prostaglandins and other eicosanoids are known as regulating agents for cellular immune responses to pathogen threats in an insect’s hemolymph. A novel synthetic peptide, WolFar, was customized from a conserved region of the Wolbachia surface protein (WSP), isolated from an economically important endoparasitoid species, Fopius arisanus. WolFar consists of nine amino acids (SYY VRL QYN) and was tested on the house cricket, Acheta domesticus. Three concentrations of peptides, 0.83 mmol/L (100%), 0.63 mmol/L (75%), and 0.42 mmol/L (50%), were injected and observed for 72 h.

10p dolomite36 30-12-2021 7 0   Download

Minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was primarily recognized as a drug for reducing vascular resistance to blood flow. It was later introduced as a more important medicine for topical stimulation of hair growth and baldness reverting as well as treatment of androgenic alopecia through increasing prostaglandin endoperoxide synthesis.

18p tudichquannguyet 29-11-2021 8 0   Download

In addition, mucus has antioxidant activity to reduce mucosal damage caused by factors produced by bacteria and immunocytes (Grisham et al., 1987). Eicosanoid bioactive lipids that include prostaglandins, leukotrienes and thromboxanes play an essential role in gastric physiology.

215p spiritedaway36 26-11-2021 6 0   Download

Diclofenac sodium (DS), a potent inhibitor of cyclooxygenase, reduces the release of arachidonic acid and formation of prostaglandins. Being a nonsteroid drug that shows antiinflammatory action, the possible side effects of fetal DS administration gain importance in public and medical applications. Herein, the effects of DS administration (1 mg/kg) during gestational days 5–20 were investigated on the performance of Wistar rat pups in a variety of behavioral tasks.

9p thiencuuchu 27-11-2021 5 0   Download

"Đánh giá kết quả khởi phát chuyển dạ ở sản phụ quá ngày sinh bằng Prostaglandin E2 tại Bệnh Viện Phụ Sản Hải Phòng năm 2019" với các mục tiêu : Đánh giá kết quả khởi phát chuyển dạ bằng Prostaglandin E2 và xác định một số yếu tố liên quan đến khởi phát chuyển dạ bằng Prostaglandin E2 trên sản phụ quá ngày sinh.

5p vikarina2711 24-08-2021 14 0   Download

Maintenance of the corpus luteum (CL) beyond the time of luteolysis is essential for establishing pregnancy. Identifying the distinct features of early pregnancy CL remains unresolved, hence we analyzed here the transcriptome of CL on day 18 pregnant (P) and non-pregnant (NP) cows using RNA-Seq.

15p vilichoo2711 23-06-2021 2 0   Download

Bài viết tiến hành đánh giá tác dụng chống loét dạ dày – tá tràng của chế phẩm dạ dày Hp Gia Phát trên động vật thực nghiệm chuột cống bị gây viêm loét dạ dày – tá tràng do cysteamin.

8p nguathienthan12 22-05-2021 13 0   Download

Recent research has focused on identifying chemical modulators of osteogenesis. We present initial findings on the osteoinductive properties of prostaglandin Е1 (Vasaprostan), using a rabbit model.

7p vioregon2711 22-02-2021 5 0   Download

The aim of this study was to evaluate the effect of the hormonal treatment on uterine involution in dystocia affected buffaloes. The experiment was carried out with total 33 buffaloes, out of which 27 were dystocia affected buffaloes presented at University clinic, GADVASU for the treatment which were further divided into 2 groups on the basis of treatment with prostaglandin and gonadotropin releasing hormone analogue (Group I: n=18, PGF2α on day 7 and GnRH on day 14 postpartum) or not (Group II: n=9, No treatment).

6p trinhthamhodang1216 19-11-2020 11 0   Download

Prostaglandin (PG) E2 plays a critical role in colorectal cancer (CRC) progression, including epithelialmesenchymal transition (EMT). Activity of the rate-limiting enzyme for PGE2 catabolism (15-hydroxyprostaglandin dehydrogenase [15-PGDH]) is dependent on availability of NAD+. We tested the hypothesis that there is intratumoral variability in PGE2 content, as well as in levels and activity of 15-PGDH, in human CRC liver metastases (CRCLM).

12p vijisoo2711 29-09-2020 5 1   Download

An n-6 essential fatty acid, arachidonic acid (ARA) is converted into prostaglandin E2, which is involved in tumour extension. However, it is unclear whether dietary ARA intake leads to cancer in humans.

27p vijisoo2711 30-09-2020 5 1   Download

Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was to examine expression of COX-2 in cancer cells and stromal cells in pancreatic cancer specimens, and to explore the role of PGE2 in pancreatic stellate cell proliferation and collagen synthesis.

13p virose2711 22-09-2020 8 1   Download