Report documents scientific research

It has been well documented that both endogenous inflammatory mediator advanced glycation end products (AGEs) and exogenous inflammatory inducer lipopolysaccharide play key roles in the initiation and development of inflammatory diseases. However, the combined inflammation-stimulatory effect of AGEs and lipopolysaccharide on endothelial cells, and, further-more, the underlying signal transduction pathways involved, have not been fully elucidated.

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Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of Ca 2+ -dependent crosslinking enzymes. Unlike other family members, TG2 is a multifunctional protein, which has several other well documented enzymatic and non-enzymatic functions.

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Dissemination is the purposive distribution of information and intervention materials to a specific public health or clinical practice audience. The intent is to spread information and the associated evidence-based interventions. Research on dissemination addresses how information about health promotion and care interventions is created, packaged,

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Address: 1Office of Quality and Performance (retired), Veterans Health Administration, U.S. Department of Veterans Affairs, Washington, DC, USA and 2U.S. Department of Veterans Affairs Midwest Health Care Network, Minneapolis, Minnesota, USA Email: Thomas J Craig - tlc1963@earthlink.net; Robert Petzel* - Robert.Petzel@va.gov * Corresponding author

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Wendy A Gifford*1, Barbara Davies1, Ian D Graham3, Nancy Lefebre2, Ann Tourangeau4 and Kirsten Woodend1 Address: 1University of Ottawa, Faculty of Health Sciences, School of Nursing, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada, 2Saint Elizabeth Health Care, 90 Allstate Parkway, Toronto, ON, Canada, 3Canadian Institute of Health Research, 160 Elgin Street, 9th Floor, Ottawa, ON, Canada and 4University of Toronto, Faculty of Nursing, 155 College Street, Toronto, ON, Canada Email: Wendy A Gifford* - wgifford@rogers.com; Barbara Davies - bdavies@uottawa.ca; Ian D Graham - IGraham@cihr-irsc.gc.

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Jane L Hutton*1, Martin P Eccles2 and Jeremy M Grimshaw3 Address: 1Department of Statistics, University of Warwick, Coventry, CV4 7AL, UK, 2Institute of Health and Society, University of Newcastle, Newcastle upon Tyne, NE2 4AA, UK and 3Clinical Epidemiology Programme, Ottawa Health Research Institute, Ottawa, Canada Email: Jane L Hutton* - J.L.Hutton@warwick.ac.uk; Martin P Eccles - martin.eccles@ncl.ac.uk; Jeremy M Grimshaw - jgrimshaw@ohri.ca * Corresponding author

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Carole A Estabrooks*1, Linda Derksen2, Connie Winther3, John N Lavis4, Shannon D Scott5, Lars Wallin6 and Joanne Profetto-McGrath7 Address: 1Faculty of Nursing, Third Floor Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada, 2Department of Sociology, Vancouver Island University, Nanaimo, British Columbia, Canada, 3Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, 4Department of Clinical Epidemiology and Biostatistics and Department of Political Science, McMaster University, Hamilton, Ontario, Canada, 5Faculty of Nursi...

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1Faculty of Nursing, University of Alberta, Edmonton, AB, Canada, 2Centre for Health Promotion Studies, School of Public Health, University of Alberta, Edmonton, AB, Canada, 3Faculty of Physical Education & Recreation, University of Alberta, Edmonton, AB, Canada, 4Alberta Centre for Active Living, University of Alberta, Edmonton, AB, Canada and 5Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland Email: Shannon D Scott* - shannon.scott@ualberta.ca; Ronald C Plotnikoff - ron.plotnikoff@ualberta.ca; Nandini Karunamuni - nandinik@chps.ualberta.

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Jamie C Brehaut*1,2, Alison Lott5, Dean A Fergusson1,2, Kaveh G Shojania6, Jonathan Kimmelman4 and Raphael Saginur1,3 Address: 1Ottawa Health Research Institute, Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada, 2Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada, 3Research Ethics Board, The Ottawa Hospital, Civic Campus, Civic Parkdale Clinic, Suite 470, 737 Parkdale Avenue, Ottawa, Ontario, K1Y 1J8, Canada, 4Biomedical Ethics Unit, McGill University, 3647 Peel S...

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Saharnaz Nedjat1, Reza Majdzadeh*1, Jaleh Gholami2, Sima Nedjat2, Katayoun Maleki2, Mostafa Qorbani3, Mostafa Shokoohi4 and Mahnaz Ashoorkhani2 Address: 1School of Public Health, Centre for Academic and Health Policy Research (CAHP), TUMS-KTE Study Group, Tehran University of Medical Sciences, Tehran, Iran, 2Centre for Academic and Health Policy Research (CAHP), TUMS-KTE Study Group, Tehran University of Medical Sciences, Tehran, Iran, 3School of Medicine, Golestan University of Medical Sciences, Golestan, Iran and 4Graduate of School of Public Health, Tehran University of Medical Sciences...

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Gaston Godin*†1, Ariane Bélanger-Gravel†2, Martin Eccles3 and Jeremy Grimshaw4,5 Address: 1Canada Research Chair on Behaviour and Health, Laval University, Québec, Canada, 2Research Group on Behaviour and Health, Faculty of Nursing, Laval University, Québec, Canada, 3Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK, 4Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada and 5Department of Medicine, University of Ottawa, Ontario, Canada Email: Gaston Godin* - Gaston.Godin@fsi.ulaval.ca; Ariane Bélanger-Gravel - Ariane.

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Tailoring an intervention to the context and system redesign related to the intervention: A case study of implementing shared medical appointments for diabetes Susan R Kirsh*1,2, Renée H Lawrence1 and David C Aron1,2 Address: 1Center for Quality Improvement Research, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA and 2School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Email: Susan R Kirsh* - susan.kirsh@va.gov; Renée H Lawrence - renee.lawrence2@va.gov; David C Aron - david.aron@va.gov * Corresponding author...

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Clinical evidence continuous medical education: a randomised educational trial of an open access e-learning program for transferring evidence-based information – ICEKUBE (Italian Clinical Evidence Knowledge Utilization Behaviour Evaluation) – study protocol Lorenzo Moja*1, Ivan Moschetti1, Michela Cinquini2, Valeria Sala1, Anna Compagnoni3, Piergiorgio Duca4, Christian Deligant5, Roberto Manfrini5, Luca Clivio6, Roberto Satolli5, Antonio Addis7, Jeremy M Grimshaw8, Pietro Dri5 and Alessandro Liberati1 Address: 1Italian Cochrane Centre, Mario Negri Institute for Pharmacological Research, M...

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Address: Health Economics and Policy Group, Division of Health Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia Email: Leonie Segal* - Leonie.Segal@unisa.edu.au; Kim Dalziel - Kim.Dalziel@unisa.edu.au; Tom Bolton - Tom.Bolton@unisa.edu.au * Corresponding author

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Address: 1South Central Mental Illness Research, Education, and Clinical Center (SC-MIRECC), Central Arkansas Veterans Healthcare System, North Little Rock, USA, 2Central Arkansas Veterans Healthcare System, HSR&D, Center for Mental Healthcare and Outcomes Research (CeMHOR), North Little Rock, USA, 3University of Arkansas for Medical Sciences, Department of Psychiatry, Division of Health Services Research, Little Rock, USA, 4Michael E.

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Cheryl B Stetler*1, Lynn McQueen2, John Demakis3 and Brian S Mittman4 Address: 1Independent Consultant, Amherst, Massachusetts, USA, 2Office of Quality and Performance, U.S. Department of Veterans Affairs, Washington DC, USA, 3(Retired) Health Services Research and Development Service, U.S. Department of Veterans Affairs, Washington, DC, USA and 4VA Center for the Study of Healthcare Provider Behavior, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA Email: Cheryl B Stetler* - Cheryl.Stetler@comcast.net; Lynn McQueen - Lynn.McQueen@va.

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Address: 1Division of General Internal Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill, NC, USA and 2Cecil G Sheps Center for Health Services Research, Chapel Hill, NC, USA Email: Carmen L Lewis* - Carmen_Lewis@med.unc.edu; Alison T Brenner - alison.brenner@unc.edu; Jennifer M Griffith - jgriffith@unc.edu; Michael P Pignone - Pignone@med.unc.edu * Corresponding author P

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Carole A Estabrooks*1, Shannon Scott1, Janet E Squires1, Bonnie Stevens2, Linda O'Brien-Pallas3, Judy Watt-Watson3, Joanne Profetto-McGrath1, Kathy McGilton4, Karen Golden-Biddle5, Janice Lander1, Gail Donner3, Geertje Boschma6, Charles K Humphrey7 and Jack Williams8 Address: 1Faculty of Nursing, University of Alberta, Edmonton, Canada, 2Faculty of Nursing, University of Toronto and Hospital for Sick Children, Toronto, Canada, 3Faculty of Nursing, University of Toronto, Toronto, Canada, 4Toronto Rehabilitation Institute, Toronto, Canada, 5School of Management, Boston University, Boston, US...

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Anne Sales*1, Christian Helfrich2, P Michael Ho3,4, Ashley Hedeen2, Mary E Plomondon3,4, Yu-Fang Li2, Alison Connors1 and John S Rumsfeld3,4 Address: 1University of Alberta, Edmonton, Alberta, Canada, 2VA Puget Sound Health Care System, Seattle, Washington, USA, 3VA Eastern Colorado Health Care System, Denver, Colorado, USA and 4University of Denver Health Sciences Center, Denver, Colorado, USA Email: Anne Sales* - anne.sales@ualberta.ca; Christian Helfrich - christian.helfrich@va.gov; P Michael Ho - michael.ho@va.gov; Ashley Hedeen - ashley.hedeen@va.gov; Mary E Plomondon - meg.

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Address: 1Veterans Affairs (VA) Health Services Research and Development (HSR&D) Center of Excellence for the Study of Healthcare Provider Behaviour, VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA and 2Department of Health Services, UCLA School of Public Health, Los Angeles, CA, USA Email: Elizabeth M Yano - elizabeth.yano@va.gov

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