Resistance and targeting

Part 1 of ebook "Biotechnology and plant disease management" provide readers with content about: unraveling microbe–plant interactions for applications to disease management; signal transduction pathways and disease resistant genes and their applications to fungal disease control; application of biotechnology to understand pathogenesis in nematode plant pathogens; molecular understanding of viroid replication cycles and identification of targets for disease management;...

314p hanlinhchi 11-11-2022 58 2   Download

The receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) is overexpressed and an important therapeutic target in Head and Neck cancer (HNC). Cetuximab is currently the only EGFR-targeting agent approved by the FDA for treatment of HNC; however, intrinsic and acquired resistance to cetuximab is a major problem in the clinic.

13p vikolindagrabar 27-07-2022 2 1   Download

Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signalling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activity, likely due to complex resistance mechanisms that are not well understood.

21p vikolindagrabar 27-07-2022 2 1   Download

Mutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10–20% of metastatic urothelial carcinomas and confer sensitivity to FGFR inhibitors. However, responses to these agents are often shortlived due to the development of acquired resistance.

11p vikolindagrabar 27-07-2022 1 1   Download

Several bone-seeking radionuclides have been developed for palliation of metastatic bone pain since 1956, however, so far radium-223 dichloride is the first and only Food and Drug Administration (FDA) approved targeted alpha therapy for metastatic castration-resistant prostate cancer (mCRPC) based on ALSYMPCA phase 3 study.

9p vikolindagrabar 27-07-2022 2 1   Download

Tyrosine kinase inhibitors (TKIs) are mainstays of cancer treatment. However, their clinical benefits are often constrained by acquired resistance. To overcome such outcomes, we have rationally engineered APG-2449 as a novel multikinase inhibitor that is highly potent against oncogenic alterations of anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 receptor tyrosine kinase (ROS1), and focal adhesion kinase (FAK).

15p vikolindagrabar 27-07-2022 2 1   Download

Although targeting of the cholesterol pathway by statins prevents breast cancer development in mouse models, efficacy is not absolute. Therefore, the goal of this study is to investigate if the upregulation in the cholesterol biosynthesis pathway genes associates with response to statin chemoprevention and may potentially be used as response biomarkers.

9p viangelamerkel 27-07-2022 1 1   Download

Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver disease stages and cirrhosis.

17p viangelamerkel 27-07-2022 1 1   Download

Ovarian cancer is initially responsive to frontline chemotherapy. Unfortunately, it often recurs and becomes resistant to available therapies and the survival rate for advanced and recurrent ovarian cancer is unacceptably low.

10p viangelamerkel 27-07-2022 2 1   Download

Serotonin (or 5-Hydroxytryptamine, 5-HT) signals in mammary gland becomes dysregulated in cancer, also contributing to proliferation, metastasis, and angiogenesis. Thus, the discovery of novel compounds targeting serotonin signalling may contribute to tailor new therapeutic strategies usable in combination with endocrine therapies.

14p viangelamerkel 27-07-2022 5 1   Download

The overexpression of aberrant cell cycle signalling pathway associated protein has been implicated in multiple malignancies and the identification of all-important one among is the crux of the precise targeted therapy.

11p visusanwojcicki 28-06-2022 4 1   Download

The bone marrow (BM) is the most common site of dissemination in patients with aggressive, meta-static neuroblastoma (NB). However, the molecular mechanisms underlying the aggressive behavior of NB cells in the BM niche are still greatly unknown. In the present study, we explored biological mechanisms that play a critical role in NB cell survival and progression in the BM and investigated potential therapeutic targets.

17p visusanwojcicki 28-06-2022 5 1   Download

Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth inhibition when JQ1 or GSK2801 were administered alone, and enhanced activity when co-administered.

21p visusanwojcicki 28-06-2022 4 1   Download

Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities need to be identified.

25p vimichaelfaraday 25-03-2022 17 1   Download

The article situates visual strategies in fraught political contexts of ramped-up police and corporate surveillance targeting Indigenous land protectors and other environmental defenders, underscoring critical concern about superficial optical allyship and hollow gestures by state actors responding to racism and state violence on Indigenous land.

18p huangminghao_1902 27-02-2022 7 1   Download

Geminiviruses cause damaging diseases in several important crop species. However, limited progress has been made in developing crop varieties resistant to these highly diverse DNA viruses. Recently, the bacterial CRISPR/Cas9 system has been transferred to plants to target and confer immunity to geminiviruses.

10p vigalileogalilei 27-02-2022 6 1   Download

Cisplatin resistance is a major challenge for advanced head and neck cancer (HNC). Understanding the underlying mechanisms and developing effective strategies against cisplatin resistance are highly desired in the clinic. However, how tumor stroma modulates HNC growth and chemoresistance is unclear.

21p vigalileogalilei 27-02-2022 8 1   Download

The CRISPR/Cas9 system has recently been engineered to confer resistance to geminiviruses in plants. However, we show here that the usefulness of this antiviral strategy is undermined by off-target effects identified by deep sequencing in Arabidopsis. We construct two virus-inducible CRISPR/Cas9 vectors that efficiently inhibit beet severe curly top virus (BSCTV) accumulation in both transient assays (Nicotiana benthamiana) and transgenic lines (Arabidopsis).

7p vigalileogalilei 27-02-2022 26 1   Download

It has been demonstrated that swine waste is an important reservoir for resistant genes. Moreover, the bacteria carrying resistant genes and originating from swine feces and wastewater could spread to the external environment. Fluoroquinolones (FQs) are widely used in livestock and poultry for the treatment of bacterial infections.

9p vigandhi 23-02-2022 13 1   Download

The CRISPR/Cas9 system provides bacteria and archaea with molecular immunity against invading phages and conjugative plasmids. Recently, CRISPR/Cas9 has been used for targeted genome editing in diverse eukaryotic species.

11p viaristotle 29-01-2022 6 0   Download