Retinoid signaling

Xem 1-6 trên 6 kết quả Retinoid signaling
  • Retinoic acid and its relatives, natural products of vitamin A metabolism, have been discovered to be critical ligands for key receptors of the steroid receptor superfamily, such as the retinoic acid receptor and the RXR receptor. Vitamins and Hormones has not had a review of this important fatsoluble vitamin for some time, and it seemed important not only to touch on the modern aspects of the retinoic acid receptor and its relatives but also of the roles of vitamin A in development and diVerentiation as well as its activity in certain tissues and in disease states....

    pdf433p thuytienvang_1 31-10-2012 28 5   Download

  • Retinoic acid receptor (RAR) and retinoid X receptor are ligand-induced transcription factors that belong to the nuclear receptor family. The receptors are activated by small hydrophobic compounds, such as all-trans-retinoic acid and 9-cis-retinoic acid, respectively. Interestingly, these receptors are also targets for a number of exogenous compounds.

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  • A pair of nuclear receptors, ecdysone receptor (EcR) and ultraspiracle (USP), heterodimerize and transduce ecdysteroid signals. The EcR and its nonsteroidal ligands are being developed for regulation of transgene expres-sion in humans, animals and plants. In mammalian cells, EcR:USP heterodimers can function in the absence of ligand, but EcR⁄retinoid X receptor (EcR:RXR) heterodimers require the presence of ligand for activa-tion.

    pdf12p dell39 27-03-2013 16 2   Download

  • Analyses of integration of two-hormone signaling through the vertebrate nuclear hormone receptors, for which the retinoid X receptor is one part-ner, have generated a number of mechanistic models, including those des-cribed as ‘subordination’ models wherein ligand-activation of one partner is subordinate to the liganded state of the other partner.

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  • Alcohol dehydrogenase (ADH) deficiency results in decreased retinol utilization, but it is unclear what physio-logical roles the several known ADHs play in retinoid signaling. Here, Adh1, Adh3,andAdh4null mutant mice have been examined following acute and chronic vitamin A excess. Following an acute dose of retinol (50 mgÆkg )1 ), metabolism of retinol to retinoic acid in liver was reduced 10-fold inAdh1mutants and 3.8-fold inAdh3mutants, but was not significantly reduced inAdh4mutants.

    pdf6p research12 29-04-2013 19 1   Download

  • Retinoid receptors are ligand-dependent transcription factors belonging to the nuclear receptor superfamily. Retinoic acid (RARa, b, c) and retinoid X (RXRa, b, c) receptors mediate the retinoid/rexinoid signal to the transcriptional machineries by interacting at the first level with coactivators or corepressors, which leads to the recruitment of enzymatically active noncovalent com-plexes at target gene promoters.

    pdf10p awards 05-04-2013 11 1   Download


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