Serologic assays

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  • A young woman confronted with a diagnosis of systemic lupus erythematosus (SLE) can expect lifelong complications arising from the disease itself, as well as the therapies used to treat this condition. About 50–70 per cent of SLE patients experience inflammation of the kidneys. As such, the young woman can expect to be treated with high doses of corticosteroids, often accompanied by the alkylating agent cyclophosphamide.

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  • Small samples and study area covering only 2 DOTS centers are some of the study limitations. Other limitations include exclusion of testing for latent TB infection (LTBI). This was as a result of shortcomings associated with use of the only available diagnostic tool- Tuberculin (Mantoux) skin test (TST). These include invasive nature of the test, the need for the patient to come back for follow up TST reading, cross-reactivity with environmental mycobacteria and previous BCG vaccination.

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  • We included studies that evaluated the performance of the most recent generation of commercial, RD1 antigen-based IGRAs (QFT-GIT and T-SPOT) among adults (age $15 years) with suspected active pulmonary tuberculosis or confirmed tuberculosis in low- and middle-income countries [22]; the World Bank Country Classification was considered as a surrogate for national tuberculosis incidence. HIV infection was established either by documented serological testing or self-report.

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  • Anti–cyclic citrullinated peptide (anti-CCP) using a peptide of filaggrin has been used extensively as a new serologic marker of rheumatoid arthritis (RA) (1,2). Many studies have confirmed that anti-CCP enzymelinked immunosorbent assay (ELISA) is as sensitive as rheumatoid factor (RF) and much more specific for RA among various rheumatic diseases (2). However, anti- CCP in other diseases has been less well studied.

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