Study epigenetic alterations

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA methylation is an evolutionally con-served mechanism to regulate gene expression in mammals.

7p media19 06-03-2013 30 1   Download

Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood. The aim of this study was to explore the expression and prognostic significance of histone protein variants in PDAC patients.

9p vimanama2711 30-07-2020 8 0   Download

The impact of biomarkers in present day health care system, health management and healthy life is enormous. Clinicians need them for diagnosis, prognosis, effect of therapeutic intervention, and most importantly, for early detection of a disease. Pharmaceutical industries need them for new drug discovery and drug efficiency test. Regulatory authorities need them for testing toxicity and environmental impact. Epidemiologists need them for population screening and risk factor determination.

402p wqwqwqwqwq 20-07-2012 74 8   Download

Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner.

11p nutifooddau 27-01-2019 16 0   Download

Epigenetics is the study of heritable changes in gene expression and other genomic functions without altering the underlying DNA sequence. It is associated with gene expression and the expression of different phenotypes mainly by a level of genetic regulation which is independent of the DNA sequence and transmitted somatically or inherited through modification of DNA regions and allows organisms on a multigenerational scale to switch between phenotypes.

9p nguaconbaynhay7 15-08-2020 8 0   Download

The 14-3-3 family is a group of intracellular proteins found in all eukaryotic organisms. Humans have seven isoforms that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in many vital cellular processes and previous studies have shown that disturbances in native 14-3-3 levels can contribute significantly to the development of various cancers.

10p vimoscow2711 29-08-2020 3 0   Download

DNA methylation is a widely studied epigenetic phenomenon; alterations in methylation patterns influence human phenotypes and risk of disease. As part of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (HM450) BeadChip was used to measure DNA methylation in peripheral blood obtained from ~3000 African American study participants.

10p vikentucky2711 26-11-2020 4 0   Download

Clonal analysis of patients with triple negative myeloproliferative neoplasm (MPN) has provided evidence of additional aberrations, including epigenetic alterations. To discover such novel genetic aberrations, patients were screened through next-generation sequencing using a myeloid sequencing panel of 54 genes using a genetic analyser. Genetic variants in 28 genes, including TET2, BCOR, BCR, and ABL1 were identified in a triple negative essential thrombocythemia (ET) patient. The individual role of some of these variants in disease pathogenesis has yet to be studied.

4p trinhthamhodang1 16-11-2019 12 0   Download

Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The aim of this study is to characterize the relationship between DNA methylation and aberrant gene expression in breast cancer.

12p viputrajaya2711 22-06-2020 4 0   Download

Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP), and global DNA methylation levels of peripheral blood leukocytes.

10p vibaku2711 22-07-2020 2 0   Download

A large number of epigenetic alterations has been found to be implicated in the etiology of gastric cancer. We have studied the DNA methylation status of 27 500 gene promoter regions in 24 gastric adenocarcinomas from a Norwegian cohort, and aimed at identifying the hypermethylated regions.

11p vinaypyidaw2711 26-08-2020 10 0   Download

The study of genetic variants alone is not enough to explain a complex disease like cancer. Alterations in DNA methylation patterns have been associated with different types of tumor. In order to detect markers of susceptibility for the development of cutaneous melanoma and breast cancer in the Uruguayan population, we integrated genetic and epigenetic information of patients and controls.

8p viamsterdam 18-09-2020 6 0   Download

It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifications and the primary objectives are to map H3K27me3 marks and quantify RAR beta 2.

15p vialabama2711 21-09-2020 6 0   Download

To understand the carcinogenesis caused by accumulated genetic and epigenetic alterations and seek novel biomarkers for various cancers, studying differentially expressed genes between cancerous and normal tissues is crucial. In the study, two cDNA libraries of lung cancer were constructed and screened for identification of differentially expressed genes.

11p vijisoo2711 29-09-2020 7 0   Download

This study explains the relations between the depositional environment of a zeolitic tuff unit and its diagenesis. It gives new ideas of the juvenile phreatomagmatic origin of the zeolitic unit with its bentonitic cap rock, and finds that the diagenetic alteration of the volcanic ash deposition in a hot hydrologic system is penecontemporaneous and not epigenetic.

21p vidonut2711 09-11-2019 5 0   Download