The heart pathways

Erythroid dematin is a major component of red blood cell junctional complexes that link the spectrin±actin cytoskel-eton to the overlying plasma membrane. Transcripts of dematinarewidelydistributed includinghumanbrain, heart, lung, skeletalmuscle, andkidney.Invitro, dematinbinds and bundles actin ®laments in a phosphorylation-dependent manner. The primary structure of dematin consists of a C-terminal domain homologous to theÔheadpieceÕ domain of villin, an actin-binding protein of the brush border cyto-skeleton. ...

12p research12 23-04-2013 42 3   Download

Macroautophagy is a vital process in the cardiac myocyte: it plays a pro-tective role in the response to ischemic injury, and chronic perturbation is causative in heart disease. Recent findings evidence a link between the apoptotic and autophagic pathways through the interaction of the anti-apoptotic proteins Bcl-2 and Bcl-XLwith Beclin 1.

14p galaxyss3 19-03-2013 40 3   Download