With total estimated

A correlated sampling technique has been implemented to estimate the impact of cross section modifications on the neutron transport and in Monte Carlo simulations in one single calculation. This implementation has been coupled to a Total Monte Carlo approach which consists in propagating nuclear data uncertainties with random cross section files.

9p christabelhuynh 29-05-2020 8 2   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 12 1   Download

Human cytochrome P450 3A4 forms a series of minor testosterone hydroxylation products in addition to 6b-hy-droxytestosterone, the major product. One of these, formed at the next highest rate after the 6b-and 2b-hydroxy prod-ucts, was identified as 1b-hydroxytestosterone. This product was characterized from a mixture of testosterone oxidation products using an HPLC-solid phase extraction-cryoprobe NMR/time-of-flight mass spectrometry system, with an estimated total of
6lgof this product.Mass spectrometry established the formula as C19H29O3(MH + 305.2080)....

8p awards 05-04-2013 41 4   Download