Polymorphism characteristics of RS165599 in COMT gene in schizophrenia patients in Kinh population
To assess the frequency allele and genotypic distribution of polymorphism rs165599 in catechol-O-methyltransferase in Kinh ethnic-patients with schizophrenia. Subjects and methods: A case-control study consisted of 227 schizophrenic patients and 92 healthy controls in the Kinh ethnic. The rs165599 was genotyped by PCR-RFLP and statistical analysis was performed by Chi-Square test. Results: The frequency of allele A and G in schizophrenic patients were 72.36% and 69.94%, respectively. The frequency of allele A and G in healthy controls were 27.64% and 30.06%, respectively (p > 0.05). In terms of distribution of AA genotype, the rate was 78.75% (patients) and 21.25% (controls). In terms of distribution of AG and GG genotype in schizophrenic patients and healthy controls were respectively: AG (66.05%, 33.95%); GG (74.03%, 25.97%) (p > 0.05). Conclusion: There was no correlation among the frequency of allele, genotypic distribution of polymorphism rs165599 and schizophrenia in the Kinh ethnic.
