Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype

Cerebral cavernous malformations are common vascular lesions of the cen-tral nervous system that predispose to seizures, focal neurologic deficits and potentially fatal hemorrhagic stroke. Human genetic studies have iden-tified three genes associated with the disease and biochemical studies of these proteins have identified interaction partners and possible signaling pathways.