5
BACKGROUND
Currently, the strong development of researches on the
mechanism of action and consequences of free radicals, as well as
oxidative stress on the body has provided evidence showing that
oxidative stress and Oxygen-free radicals are also a pathological
factor involved in the development of colon cancer.
In particular, the results of many studies show that oxidative
stress and the presence of oxygen-free radicals, produced during
surgery removing colon cancer, also play an important role in relapse
and metastasis after surgery. Therefore, the study of changes in
oxidative stress after surgery is currently of interest to many
researchers. There are many indices to assess oxidative stress status,
but in the studies, the most widely and commonly applied index to
indirectly assess oxidative stress in general and in abdominal surgery
in particular is Malondialdehyde (MDA), a product of lipid
peroxidation.
In Vietnam, not many studies mentioned the issue of oxidative
stress in colon cancer and exploring the changes in MDA content
after radical surgery for colon cancer treatment. Therefore, we
conducted the topic “Research on the changes in Malondialdehyde
content in patients with colon cancer before and after radical
surgery” with the following goals:
1. Study the Malondialdehyde content in patients with colon
cancer who underwent radical surgery treatment.
2. Evaluate the changes in red blood cell Malondialdehyde
content of patients with colon cancer after radical surgery.
Layout of the thesis
The thesis consists of 124 pages, including the following parts:
