.MINISTRY OF EDUCATION AND
TRAINING
MINISTRY OF
DEFENCE
VIETNAM MILITARY MEDICAL UNIVERSITY
NGUYEN THI THANH MAI
METABOLIC SYNDROME, PLASMA LEPTIN
AND IL-1 CONCENTRATIONS IN PATIENTSβ
WITH PRIMARY KNEE OSTEOARTHRITIS
Speciality : INTERNAL MEDICINE
Code : 9 72 01 07
THE SUMMARY OF THE MEDICAL DOTORAL THESIS
HANOI – 2019
THIS DOCTORAL THESIS WAS COMPLETED
AT VIETNAM MILITARY MEDICAL UNIVERSITY
Scientific Instructors:
1. A/PROF. Ph.D. Do Trung Quan
2. A/PROF. Ph.D. Dao Hung Hanh
1st Contradictor: A/PROF. Ph.D. Nguyen Thanh Thuy
2nd Contradictor: PROF. Ph.D. Vo Tam
3rd Contradictor: A/PROF. Ph.D. Doan Van De
The doctoral thesis will be reported to The Grading and
Examinations Committee hold at Vietnam Military Medical
University at 2019
Searching for the dissertation at:
-National Library
-Vietname Military Medical University’s library
INTRODUCTION
Osteoarthritis (OA) was the result of interaction between
biomechanics and chronic low-stage inflammation. Metabolic syndrome
(MS) included central obesity, dyslipidemia, impaired fasting glucose,
and hypertension in which obesity was the most important. The
prevalence of MS increased in the OA compared with the non-OA
group. Obesity was a significant risk factor for knee OA (KOA) through
mechanisms of increasing mechanical load and chronic low-stage
inflammation. Low-stage chronic inflammation associated with
adipokines (leptin) interacts with pro-inflammatory cytokines of which
interleukin1 (IL-1 ) was a key role in maintaining cartilage ulcers,β β
substrate degradation in obesity pathogenesis mechanism caused OA.
Therefore, the thesis “Metabolic syndrome, plasma leptin and
IL-1 βconcentrations in patients with primary knee osteoarthritis”
was conducted with two objectives:
1. To determine the prevalence of metabolic syndrome, its
components and the relationship with the stages of primary knee
osteoarthritis.
2. To determine the relationship of plasma leptin and IL-1β
concentrations with some clinical and subclinical features in patients
with primary knee osteoarthritis.
* The scientific significance: Increasing the incidence of MS in
the OA, MS and OA were shared the pathogenesis mechanism
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related to obesity, low-stage chronic inflammatory response and
adipokines (leptin) or pro-inflammatory cytokines (IL-1 ).β
* The practical significance: Described the specific value of the
prevalence of MS, plasma leptin and IL-1 concentrations in βKOA and
compared with the control. It was recommended to identify a KOA
patient with MS accompanying control of two problems simultaneously.
Leptin should be quantified in patients with KOA who do not meet the
diagnostic criteria for MS, to determine a group of KOA patients at high
risk of MS, for early intervention.
* New contributions of this doctoral thesis
This was the first scientific study in Vietnam on MS, plasma leptin
and IL-1 concentrations in patients with primary KOA. The βprevalence
of MS in KOA was 51.7% and its increased when the stage of KOA
increased.
Determination of plasma leptin and IL-1 concentrations of the KOAβ
patients were higher than the control; the correlation between leptin and
IL-1 were determined with some metabolic risk factors. Determinationβ
of the cut-off point of plasma leptin concentrations that predicts a patient
with knee osteoarthritis who may suffer from MS.
* The doctoral thesis arrangement: This thesis contains 125 pages
(without references and appendixes): Introduction: 02 pages, Chapter
1 Overview: 35 pages, Chapter 2 Subjects and methods: 28 pages,
Chapter 3 Results: 32 pages, Chapter 4 Discussion: 37 pages,
Conclusion: 02 pages, Recommendations: 01 page. It includes 33
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tables, 9 graphs, 16 figures, 1 diagram and 174 references (7
Vietnamese references and 167 English references).
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