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INTRO DUCTION
1. The urgency of thesis
Septic shock is an acute circulatory failure that reduces the
perfusion of organs, promotes systemic inflammatory response and
prolonged metabolic disorders, leading to multiple organ failure and
death. Early identification and effective management reduce
mortality in septic shock. Biomarkers have an important role in
diagnosis as well as prognosis of septic shock.
Currently there are many biomarkers that help diagnose and
prognosis patients with septic shock such as CRP, PCT, presepsin ...
Presepsin is a soluble molecule of CD14, created when the body
responds to infection. Many studies show that presepsin is valuable
in early diagnosis (up to 2 hours after infection) sepsis and septic
shock. Some meta-analyzes have demonstrated that presepsin has
better value than PCT in the diagnosis and prognosis of sepsis and
septic shock. In Vietnam, no studies to evaluated the role of plasma
presepsin in diagnosis and prognosis sepsis and septic shock.
2. The meaning of thesis
The thesis contributes new to theory and practice of using
biomarkers presepsin in the direction of diagnosis and prognosis in
patients with severe sepsisand septic shock, thereby allowing the use of
presepsin as a tool. diagnosis, monitoring and prognosis for patients
with severe sepsisand septic shock.
This is the first study in Vietnam.
3. Objectives
- Evaluate concentration changes and the role of plasma
presepsin in diagnosing severe sepsisand septic shock.
- Determine the correlation of plasma presepsin with some
scales and biomarkers assessing the severity in prognosis of
mortality on patients with severe sepsis and septic shock.
