Báo cáo khoa học: Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 Partial characterization of the inhibitory epitope and potential applications
The study and therapeutic modulation of purinergic signaling is hindered
by a lack of specific inhibitors for NTP diphosphohydrolases (NTPDases),
which are the terminating enzymes for these processes. In addition, little is
known of the NTPDase protein structural elements that affect enzymatic
activity and which could be used as targets for inhibitor design.
