Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles

Current evidence indicates that chylomicron remnants (CMR) induce macrophage foam cell formation, an early event in atherosclerosis. Inflam-mation also plays a part in atherogenesis and the transcription factor nuclear factor-jB (NF-jB) has been implicated. In this study, the influence of CMR on the activity of NF-jB in macrophages and its modulation by the fatty acid composition of the particles were investigated using macro-phages derived from the human monocyte cell line THP-1 and CMR-like particles (CRLPs)....