Neuromuscular Junction Disorders Diagnosis and Treatment
Diseases of the neuromuscular junction (NMJ) include a large spectrum of
acquired and inherited disorders mainly characterized by fluctuating muscle
weakness and fatigability of ocular, bulbar or limb muscles. Remarkable
progress has been made in our understanding of the pathogenesis of these
disorders in recent years. Furthermore, our ability to diagnose these conditions
has improved significantly due to the widespread availability of immunologic
tests, the use of in vitro electrophysiologic and microstructural
studies, and the refinement of sensitive clinical electrodiagnostic tests of neuromuscular
transmission. Despite these advances, significant questions remain
to be answered by the researcher and the clinician, and disagreement
exists amongst specialists regarding therapy and management of patients.
This...