Alzheimer pathogenesis

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  • In 1871, over 30 years before Alois Alzheimer published his seminal cases, James Crichton - Browne may have been among the fi rst physicians to remark upon the relationship between “ brain wasting ” and “ premature dotage ” in a letter to Charles Darwin (Snyder & Pearn, 2007 ). Age - related mental deterioration as an entity had been recognized virtually for recorded history (Boller et al., 2007 ; Mandell & Albert, 1990 ).

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  • In the early 1990s, breakthrough discoveries on the genetics of Alzheimer’s disease led to the identification of missense mutations in the amyloid-b precursor proteingene. Research findings quickly followed, giving insights into molecular pathogenesis and possibilities for the development of new types of animal models.

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  • The dawn of psychogeriatrics in Japan was celebrated with the symposium entitled ‘Psychiatry for the Elderly’ in the frame of the annual meeting of the Japanese Society of Psychiatry and Neurology in 1954, on which occasion Professor Ziro Kaneko (Osaka University), Professor Tadashi Inose (Yokohama City University), and Professor Naotake Shinfuku (Tottori University) delivered their lectures on the psychological process of aging, neuropathology of aging and psychopathology of aging, respectively.

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  • Central to the development of glomerular inflammation and injury are alterations and abnormalities of various cytokines and signaling systems. There are four chapters in this book that deal with these aspects in the pathogenesis. The role of TGF-β in progressive glomerular disease is discussed in great detail in a chapter well written by Hyun Soon Lee, with particular reference to mesangial matrix accumulation, while the role of STAT3 activation in glomerulonephritis is elaborated in the well written chapter by Fumio Tsuji et al.

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  • Nhiều vấn đề chưa được giải quyết tiếp tục với bệnh dịch hạch sự hiểu biết của chúng ta về sinh bệnh học của AD. Mặc dù biết rằng cái chết của tế bào thần kinh có thể xảy ra do NFT hình thành và bệnh mạch máu não

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  • Một số các nghiên cứu kiểm tra giới tính như là một yếu tố nguy cơ AD tìm thấy một nguy cơ gia tăng ở phụ nữ, nhất là phụ nữ lớn tuổi, thậm chí sau khi kiểm soát mức độ giáo dục và các yếu tố khác, chẳng hạn như tỉ lệ sống sót khác biệt giữa các.

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  • nhưng thường được tìm thấy được từ 1,5 đến 2 lần so với các nhóm tài liệu tham khảo giáo dục cao hơn. Tuy nhiên, việc tìm thấy một mối liên hệ giữa giáo dục và AD là bởi không có nghĩa là phổ quát

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  • Các thay đổi Neuropathological trong basalis hạt nhân tương quan với các biện pháp lâm sàng của bệnh sa sút trí tuệ. Acta Neuropathol. 98, 186-196. Irina, A., Seppo, H., Arto, M., Paavo, Thánh, R., và Hilkka, S. (1999). tải fl-amyloid không bị ảnh hưởng bởi mức độ nghiêm trọng của bệnh tim mạch ở bệnh nhân

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  • In the century since the neuronal inclusions [neurofibrillary tangles (NFTs); Fig. 1] and extracellular protein aggregates (Aft plaques; Fig. 1) that form the pathological hallmarks of Alzheimer's disease (AD) were described, our knowledge of all aspects of AD has grown markedly. AD is uniformly progressive and ultimately results in debilitating cognitive impairment. In the early stages, the impairment may only be apparent on neuropsychological testing; however, by end stage, few functions above the automatic remain unaffected (Forstl and Kurz, 1999)....

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  • The amyloidbpeptide (Ab) is crucial for the pathogenesis of Alzheimer’s disease. Aggregation of monomeric Ab into insoluble amyloid fibrils proceeds through several soluble Abintermediates, including protofibrils, which are believed to be central in the disease process. The main reason for this is their implication in familial Alzheimer’s disease with the Arctic amyloid precursor protein mutation (E693G).

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  • Chẩn đoán các vấn đề A. A / 3 mảng vữa và NFTs Đánh giá B. Chẩn đoán bệnh lý của O có các bệnh lý tương quan lâm sàng C. AD lặp lại Bệnh Học D. C urrent lâm sàng Chẩn đoán giao thức E. S ummary III. Sinh bệnh não Atrophy A. B. tế bào thần kinh Mất

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The contribution of activated astrocytes to Ab production: Implications for Alzheimer’s disease pathogenesis

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  • Metal binding to the amyloidb-peptide is suggested to be involved in the pathogenesis of Alzheimer’s disease. We used high-resolution NMR to study zinc binding to amyloid b-peptide 1–40 at physiologic pH. Metal binding induces a structural change in the peptide, which is in chemical exchange on an intermediate rate, between the apo-form and the holo-form, with respect to the NMR timescale.

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  • Recently, a novel plaque-associated protein, collagenous Alzheimer amy-loid plaque component (CLAC), was identified in brains from patients with Alzheimer’s disease. CLAC is derived from a type II transmembrane colla-gen precursor protein, termed CLAC-P (collagen XXV). The biological function and the contribution of CLAC to the pathogenesis of Alzheimer’s disease and plaque formation are unknown.

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  • The pathogenesis of formation of neurofibrillary tangles (NFTs) in Alzhei-mer’s disease (AD) brains is unknown. One of the possibilities might be that translation of tau mRNA is aberrantly regulated in AD brains.

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  • The amyloid precursor family of proteins are of considerable interest, both because of their role in Alzheimer’s disease pathogenesis and because of their normal physiological functions. In mammals, the amyloid precursor protein (APP) has two homologs, amyloid precursor-like protein (APLP) 1 and APLP2.

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  • The interaction of theb-amyloid peptide (Ab) with neuronal membranes could play a key role in the pathogenesis of Alzheimer’s disease. Recent studies have focused on the interactions of Aboligomers to explain the neuronal toxicity accompanying Alzheimer’s disease.

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  • Neurodegenerative disorders are common and devastating. Rationally, the most effective treatments will target pathogenetic mechanisms. While alternative approaches, based on alleviating the symptoms of patients with Alzheimer disease, Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sclerosis, can be expected to reduce suffering, studies of pathogenesis of these agerelated disorderswill be most important for enabling early diagnosis and the creation of preventative and curative treatments.

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  • There is strong evidence thatb-amyloid (Ab) causes oxidative stress and induces mitochondrial dysfunction in the pathogenesis of Alzheimer’s dis-ease. Mitochondrial transcription factor A (Tfam) has multiple roles in the maintenance of mtDNA. To study the protective roles of Tfam against amyloid neurotoxicity, we established SH-SY5Y cell lines stably over-expressing Tfam and exposed them to 10lmAb1-42 for 24 h.

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  • Oligomeric assemblies of amyloid-b(Ab) are suggested to be central in the pathogenesis of Alzheimer’s disease because levels of soluble Abcorrelate much better with the extent of cognitive dysfunctions than do senile plaque counts. Moreover, such Abspecies have been shown to be neurotoxic, to interfere with learned behavior and to inhibit the maintenance of hippo-campal long-term potentiation.

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